氯氮平继发的白细胞破碎性血管炎。
Leukocytoclastic vasculitis secondary to clozapine.
作者信息
Mukherjee Shatavisa, Era Nikhil, Mukherjee Mala, Tripathi Santanu Kumar
机构信息
Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India.
Department of Pharmacology, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India.
出版信息
Indian J Psychiatry. 2019 Jan-Feb;61(1):94-96. doi: 10.4103/psychiatry.IndianJPsychiatry_384_18.
Leukocytoclastic vasculitis (LCV) may be secondary to drugs, underlying infection, collagen vascular disorders, or malignancy. Drug-induced vasculitis contributes to 10% of vasculitic skin lesions cases usually developing within 7-21 days of treatment initiation. The present case highlights a report of LCV in a 59-year-old male with a history of paranoid schizophrenia on clozapine therapy. The report upsurges the need to promote awareness and expedite diagnosis and treatment of drug-induced LCVs.
白细胞破碎性血管炎（LCV）可能继发于药物、潜在感染、胶原血管疾病或恶性肿瘤。药物性血管炎占血管性皮肤病变病例的10%，通常在开始治疗后7 - 21天内发生。本病例报告了一名59岁男性，有偏执型精神分裂症病史，正在接受氯氮平治疗，发生了白细胞破碎性血管炎。该报告强调了提高对药物性白细胞破碎性血管炎的认识并加快其诊断和治疗的必要性。
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