Stringer B M, Rowson J, Williams E D
Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
J Anat. 1989 Feb;162:249-61.
The effect of serum prolactin elevation on the growth and development of the rat breast was investigated. Oral administration of the dopamine antagonist, perphenazine, led to a 5-10-fold elevation of serum prolactin after two days of treatment which was maintained for the 54 days of study. A significant (P less than 0.01) 3.4-fold increase in total breast volume was seen by Day 4 of serum prolactin elevation. Breast volume continued to rise up to Day 14 reaching an 8.9-fold peak (P less than 0.001) which was maintained for the duration of the experiment. Epithelial, myoepithelial, lumen and stromal volume changes in the ductular and alveolar compartments were quantified separately. Highly significant (P less than 0.01) volume increases were seen in all components within the first few days of prolactin elevation. Similar time courses of the growth response to elevated serum prolactin were seen in the ductal tissues reaching an approximate 3-fold peak by 7 days in duct epithelium, myoepithelium and duct stroma. Time coordinated growth responses were also seen in the alveolar tissues with larger (7-15-fold) increases in alveolar epithelium, alveolar myoepithelium and alveolar stroma, reaching a peak by 14 days.
研究了血清催乳素升高对大鼠乳腺生长发育的影响。口服多巴胺拮抗剂奋乃静，在治疗两天后血清催乳素升高5至10倍，并在为期54天的研究中持续保持。在血清催乳素升高的第4天，可见乳腺总体积显著（P<0.01）增加3.4倍。乳腺体积持续上升，直至第14天达到8.9倍峰值（P<0.001），并在实验期间保持。分别对导管和腺泡区的上皮、肌上皮、管腔和基质体积变化进行了量化。在催乳素升高的最初几天内，所有成分的体积均显著（P<0.01）增加。在导管组织中观察到对血清催乳素升高的生长反应具有相似的时间进程，导管上皮、肌上皮和导管基质在7天时达到约3倍的峰值。在腺泡组织中也观察到时间协调的生长反应，腺泡上皮、腺泡肌上皮和腺泡基质有更大（7至15倍）的增加，在14天时达到峰值。
