Davies Olubanke, Costelloe Sinead, Cross Gemma, Dew Tracy, O'Shea Siobhan, White John, Fox Julie
1 Department of Genitourinary & HIV medicine, Guy's & St Thomas' NHS Foundation Trust, Westminster Bridge road, London, UK.
2 Directorate of Infection, Guy's & St Thomas' NHS Foundation Trust, Westminster Bridge road, London, UK.
Int J STD AIDS. 2017 Sep;28(10):1034-1037. doi: 10.1177/0956462416686513. Epub 2017 Jan 12.
The aim of this study was to investigate the effect of asymptomatic rectal bacterial sexually transmitted infections (STIs) on rectal HIV viral load (VL). A prospective cohort study of HIV-positive men who have sex with men attending a tertiary centre in London, UK, for their routine HIV care was performed. Forty-two HIV-positive men who have sex with men were recruited between January and August 2014. In participants on antiretroviral therapy (ART), there was no significant difference in rectal VL in those with and without STI ( p = 0.4). All rectal HIV VLs were below the limit of detection (<100 copies/µg of total RNA) whether an STI was present or not. In those not on ART, rectal HIV VL was on average 0.6log lower post STI treatment. The presence of asymptomatic rectal chlamydia and gonorrhoea was not associated with increased rectal HIV VL in those fully suppressed on ART. In the context of effective ART, the presence of rectal gonorrhoea or chlamydia does not appear to increase rectal HIV VL and the risk of increased viral infectivity.
本研究的目的是调查无症状直肠细菌性性传播感染（STIs）对直肠HIV病毒载量（VL）的影响。对在英国伦敦一家三级医疗中心接受常规HIV护理的男男性行为HIV阳性者进行了一项前瞻性队列研究。2014年1月至8月招募了42名男男性行为HIV阳性者。在接受抗逆转录病毒治疗（ART）的参与者中，有STI和无STI者的直肠VL无显著差异（p = 0.4）。无论是否存在STI，所有直肠HIV VL均低于检测下限（<100拷贝/μg总RNA）。在未接受ART的参与者中，STI治疗后直肠HIV VL平均降低0.6log。在接受ART充分抑制的人群中，无症状直肠衣原体和淋病的存在与直肠HIV VL升高无关。在有效的ART背景下，直肠淋病或衣原体的存在似乎不会增加直肠HIV VL以及病毒传染性增加的风险。
J Acquir Immune Defic Syndr. 2018-7-1
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