2型糖尿病的治疗途径及脂肪因子的当前研究视角
Treatment Avenues for Type 2 Diabetes and Current Perspectives on Adipokines.
作者信息
Pramanik Sayantani, Rathwa Nirali, Patel Roma, Ramachandran A V, Begum Rasheedunnisa
机构信息
Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
出版信息
Curr Diabetes Rev. 2018;14(3):201-221. doi: 10.2174/1573399813666170112142837.
BACKGROUND
Diabetes has turned into a pandemic disorder that is affecting millions of people worldwide. Industries are aggressively racing and pursuing research towards the discovery of antidiabetic drug and the current global sale of such drugs are ever on the increase. However, in spite of such massive level of expenditure thereof, WHO projects that by 2030, diabetes will rank as the 7th leading cause of mortality.
OBJECTIVE
It is in this context that we have reviewed here the various approaches available and possible towards diabetes management. This review also includes the WHO guidelines for controlling the glycemic levels, which must be known and followed by clinicians for a better diabetes management.
CONCLUSION
Despite having a wealth of FDA-approved therapeutic options for type 2 diabetes majorities of the patients are not able to achieve the appropriate glycemic control due to various factors. The development of new options with actions at multiple foci of diabetic manifestation and better efficacy may potentially help in improving the current scenario of T2D management.
背景
糖尿病已成为一种大流行疾病，正在影响全球数百万人。各行业正在积极竞争并开展研究以发现抗糖尿病药物，此类药物目前的全球销售额也在不断增长。然而，尽管在这方面投入了大量资金，但世界卫生组织预计，到2030年，糖尿病将成为第七大主要死因。
目的
正是在这种背景下，我们在此回顾了糖尿病管理可用的各种方法和可能的方法。本综述还包括世界卫生组织控制血糖水平的指南，临床医生必须了解并遵循这些指南，以更好地管理糖尿病。
结论
尽管有大量经美国食品药品监督管理局批准的2型糖尿病治疗选择，但由于各种因素，大多数患者仍无法实现适当的血糖控制。开发在糖尿病表现的多个靶点起作用且疗效更佳的新选择可能有助于改善目前2型糖尿病的管理状况。
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