Christopher Kara M, Osazuwa-Peters Nosayaba, Dougherty Rebecca, Indergaard Sarah A, Popp Christina, Walker Ronald, Varvares Mark A
Saint Louis University Cancer Center, 3655 Vista Avenue, Saint Louis, MO 63110, USA.
Saint Louis University Cancer Center, 3655 Vista Avenue, Saint Louis, MO 63110, USA; Saint Louis University, School of Medicine, Department of Otolaryngology-Head and Neck Surgery, 3635 Vista Avenue, Saint Louis, MO 63110, USA.
Am J Otolaryngol. 2017 Mar-Apr;38(2):168-173. doi: 10.1016/j.amjoto.2016.12.003. Epub 2016 Dec 29.
The objective of this pilot study was to determine how different treatment modalities (surgery, radiation, and chemotherapy) impact quality of life (QOL) in a population of head and neck cancer (HNC) survivors.
Fifty-nine newly diagnosed, biopsy-confirmed HNC patients were recruited between 2007-2012. They completed the EORTC Quality of Life Questionnaire and Head & Neck Module at 5 intervals pre- and post-treatment. Participants were grouped into four categories based on modality: surgery only, surgery/radiation, chemoradiation, or surgery/chemoradiation. Repeated measures ANOVA examined effect of treatment modality on QOL over time.
Xerostomia symptoms were significantly associated with chemoradiation (F(2.47, 59.27)=3.57, p=0.03), lowest at pretreatment and highest 6 months post-treatment. Time was significantly associated with head and neck pain, F(2.95,67.89)=3.39, p=0.02.
HNC survivors exhibit different QOL related symptoms depending on combined treatment modalities, and time post-treatment. It is important to understand QOL differences based upon treatment modalities when developing treatment plans for HNC patients.
本初步研究的目的是确定不同治疗方式（手术、放疗和化疗）如何影响头颈癌（HNC）幸存者群体的生活质量（QOL）。
2007年至2012年期间招募了59例新诊断的、经活检确诊的HNC患者。他们在治疗前和治疗后的5个时间点完成了欧洲癌症研究与治疗组织生活质量问卷和头颈模块。参与者根据治疗方式分为四类：单纯手术、手术/放疗、放化疗或手术/化疗。重复测量方差分析检验了治疗方式随时间对生活质量的影响。
口干症状与放化疗显著相关（F(2.47, 59.27)=3.57, p=0.03），在治疗前最低，治疗后6个月最高。时间与头颈疼痛显著相关，F(2.95,67.89)=3.39, p=0.02。
HNC幸存者根据联合治疗方式和治疗后时间表现出不同的与生活质量相关的症状。在为HNC患者制定治疗计划时，了解基于治疗方式的生活质量差异很重要。
