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Long-term relapse-free survival in a phase 2 study of blinatumomab for the treatment of patients with minimal residual disease in B-lineage acute lymphoblastic leukemia.在一项关于博纳吐单抗治疗B系急性淋巴细胞白血病微小残留病患者的2期研究中的长期无复发生存率
Haematologica. 2017 Apr;102(4):e132-e135. doi: 10.3324/haematol.2016.153957. Epub 2017 Jan 12.
2
Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL.在一项blinatumomab 治疗 B 系 ALL 患者微小残留病的 2 期研究中，血液学无复发生存的长期随访结果。
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Clearance of minimal residual disease after allogeneic stem cell transplantation and the prediction of the clinical outcome of adult patients with high-risk acute lymphoblastic leukemia.异基因造血干细胞移植后微小残留病的清除及高危成人急性淋巴细胞白血病临床结局的预测
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Pediatric posttransplant relapsed/refractory B-precursor acute lymphoblastic leukemia shows durable remission by therapy with the T-cell engaging bispecific antibody blinatumomab.儿童移植后复发/难治性B前体急性淋巴细胞白血病通过使用T细胞接合双特异性抗体博纳吐单抗治疗显示出持久缓解。
Haematologica. 2014 Jul;99(7):1212-9. doi: 10.3324/haematol.2013.100073. Epub 2014 Apr 11.
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Long-term survival and T-cell kinetics in relapsed/refractory ALL patients who achieved MRD response after blinatumomab treatment.在接受博纳吐单抗治疗后达到微小残留病（MRD）缓解的复发/难治性急性淋巴细胞白血病（ALL）患者中的长期生存和T细胞动力学
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Durable remissions in positive acute lymphoblastic leukemia with blinatumomab and stem cell transplantation.使用博纳吐单抗和干细胞移植治疗阳性急性淋巴细胞白血病的持久缓解。
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Concurrent blinatumomab and donor lymphocyte infusions for treatment of relapsed pre-B-cell ALL after allogeneic hematopoietic cell transplant.同时使用博纳吐单抗和供体淋巴细胞输注治疗异基因造血细胞移植后复发的前B细胞急性淋巴细胞白血病。
Bone Marrow Transplant. 2016 Sep;51(9):1253-5. doi: 10.1038/bmt.2016.104. Epub 2016 Apr 18.
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Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study.Blinatumomab 治疗成人复发/难治性 B 前体急性淋巴细胞白血病患者的安全性和疗效：一项多中心、单臂、2 期研究。
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GNA15 induces drug resistance in B cell acute lymphoblastic leukemia by promoting fatty acid oxidation via activation of the AMPK pathway.GNA15通过激活AMPK途径促进脂肪酸氧化，从而诱导B细胞急性淋巴细胞白血病产生耐药性。
Mol Cell Biochem. 2025 Jun;480(6):3719-3733. doi: 10.1007/s11010-024-05198-4. Epub 2025 Jan 15.
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Bispecific T-cell engagers in childhood B-acute lymphoblastic leukemia.双特异性 T 细胞衔接器在儿童 B 急性淋巴细胞白血病中的应用。
Haematologica. 2024 Jun 1;109(6):1668-1676. doi: 10.3324/haematol.2023.283818.
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All about blinatumomab: the bispecific T cell engager immunotherapy for B cell acute lymphoblastic leukemia.关于博纳吐单抗：用于B细胞急性淋巴细胞白血病的双特异性T细胞衔接器免疫疗法。
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PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia.PAX5 通过表观遗传调控 CD58 的转录，调节急性淋巴细胞白血病中blinatumomab 的反应。
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Clinical Development and Therapeutic Applications of Bispecific Antibodies for Hematologic Malignancies.双特异性抗体在血液系统恶性肿瘤中的临床开发与治疗应用
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本文引用的文献

1
Long-term survival and T-cell kinetics in relapsed/refractory ALL patients who achieved MRD response after blinatumomab treatment.在接受博纳吐单抗治疗后达到微小残留病（MRD）缓解的复发/难治性急性淋巴细胞白血病（ALL）患者中的长期生存和T细胞动力学
Blood. 2015 Dec 10;126(24):2578-84. doi: 10.1182/blood-2015-06-649111. Epub 2015 Oct 19.
2
Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study.Blinatumomab 治疗成人复发/难治性 B 前体急性淋巴细胞白血病患者的安全性和疗效：一项多中心、单臂、2 期研究。
Lancet Oncol. 2015 Jan;16(1):57-66. doi: 10.1016/S1470-2045(14)71170-2. Epub 2014 Dec 16.
3
Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia.抗 CD19 双特异性 T 细胞衔接蛋白blinatumomab 的 II 期临床试验显示，复发或难治性 B 前体急性淋巴细胞白血病患者有血液学和分子缓解。
J Clin Oncol. 2014 Dec 20;32(36):4134-40. doi: 10.1200/JCO.2014.56.3247. Epub 2014 Nov 10.
4
Long-term follow-up of serum immunoglobulin levels in blinatumomab-treated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia.在接受blinatumomab治疗的微小残留病阳性B前体急性淋巴细胞白血病患者中血清免疫球蛋白水平的长期随访
Blood Cancer J. 2014 Sep 5;4(9):244. doi: 10.1038/bcj.2014.64.
5
Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL.在一项blinatumomab 治疗 B 系 ALL 患者微小残留病的 2 期研究中，血液学无复发生存的长期随访结果。
Blood. 2012 Dec 20;120(26):5185-7. doi: 10.1182/blood-2012-07-441030. Epub 2012 Sep 28.
6
Blinatumomab: a historical perspective.Blinatumomab：历史视角。
Pharmacol Ther. 2012 Dec;136(3):334-42. doi: 10.1016/j.pharmthera.2012.07.013. Epub 2012 Aug 24.
7
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab.B 系急性淋巴细胞白血病患者对 T 细胞结合 CD19/CD3 双特异性 BiTE 抗体blinatumomab 持续输注的免疫药理学反应。
Blood. 2012 Jun 28;119(26):6226-33. doi: 10.1182/blood-2012-01-400515. Epub 2012 May 16.
8
Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies.急性淋巴细胞白血病伴分子学复发的成年患者预后不良，是干细胞移植和靶向治疗的候选人群。
Blood. 2012 Aug 30;120(9):1868-76. doi: 10.1182/blood-2011-09-377713. Epub 2012 Mar 22.
9
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.针对化疗耐药的 B 系急性淋巴细胞白血病患者微小残留病灶的 T 细胞结合抗体blinatumomab 的靶向治疗可带来高缓解率和延长无白血病生存。
J Clin Oncol. 2011 Jun 20;29(18):2493-8. doi: 10.1200/JCO.2010.32.7270. Epub 2011 May 16.

Long-term relapse-free survival in a phase 2 study of blinatumomab for the treatment of patients with minimal residual disease in B-lineage acute lymphoblastic leukemia.

作者信息

Gökbuget Nicola, Zugmaier Gerhard, Klinger Matthias, Kufer Peter, Stelljes Matthias, Viardot Andreas, Horst Heinz A, Neumann Svenja, Brüggemann Monika, Ottmann Oliver G, Burmeister Thomas, Wessiepe Dorothea, Topp Max S, Bargou Ralf

机构信息

Center of Internal Medicine, Goethe University, Frankfurt, Germany.

Amgen Research (Munich) GmbH, Germany

出版信息

Haematologica. 2017 Apr;102(4):e132-e135. doi: 10.3324/haematol.2016.153957. Epub 2017 Jan 12.

DOI:10.3324/haematol.2016.153957
PMID:28082340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5395124/
Abstract
摘要