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1
Editorial: HSPs-Ambiguous Mediators of Immunity.社论：热休克蛋白——免疫的模糊介质
Front Immunol. 2016 Dec 26;7:639. doi: 10.3389/fimmu.2016.00639. eCollection 2016.
2
An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis.
J Immunol. 1998 May 1;160(9):4628-34.
3
Mycobacterial Hsp65-IgG-expressing tolerogenic B cells confer protection against adjuvant-induced arthritis in Lewis rats.表达分枝杆菌热休克蛋白65-免疫球蛋白的耐受性B细胞可保护Lewis大鼠免受佐剂诱导的关节炎。
Arthritis Rheum. 2007 May;56(5):1490-6. doi: 10.1002/art.22566.
4
Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.佐剂性关节炎诱导或保护性免疫方案后分枝杆菌65 kDa热休克蛋白T细胞表位的差异性识别
J Immunol. 1994 Apr 1;152(7):3656-64.
5
CD4+ Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced arthritis.针对分枝杆菌65千道尔顿热休克蛋白的CD4 + Th2细胞可预防 pristane 诱导的关节炎。
J Immunol. 1997 Oct 15;159(8):3692-7.
6
Mycobacterial Hsp65 potentially cross-reacts with autoantibodies of diabetes sera and also induces (in vitro) cytokine responses relevant to diabetes mellitus.分枝杆菌热休克蛋白65可能与糖尿病患者血清中的自身抗体发生交叉反应，并且（在体外）还会诱导与糖尿病相关的细胞因子反应。
Mol Biosyst. 2013 Nov;9(11):2932-41. doi: 10.1039/c3mb70307j.
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Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient mice.口服乳球菌 delivered 热休克蛋白 65 可减轻低密度脂蛋白受体缺陷小鼠的动脉粥样硬化。
Vaccine. 2011 May 31;29(24):4102-9. doi: 10.1016/j.vaccine.2011.03.105. Epub 2011 Apr 15.
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DNA vaccine using hemagglutinating virus of Japan-liposome encapsulating combination encoding mycobacterial heat shock protein 65 and interleukin-12 confers protection against Mycobacterium tuberculosis by T cell activation.使用日本血凝病毒-脂质体包裹组合的DNA疫苗，该组合编码分枝杆菌热休克蛋白65和白细胞介素-12，通过激活T细胞赋予对结核分枝杆菌的保护作用。
Vaccine. 2006 Feb 20;24(8):1191-204. doi: 10.1016/j.vaccine.2005.08.103. Epub 2005 Sep 19.
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In-vitro effects of Mycobacterium bovis BCG-lysate and its derived heat shock proteins on cytokines secretion by blood mononuclear cells of rheumatoid arthritis patients in comparison with healthy controls.牛分枝杆菌卡介苗裂解物及其衍生热休克蛋白对类风湿关节炎患者血液单核细胞细胞因子分泌的体外作用，并与健康对照进行比较。
Int Immunopharmacol. 2008 Jun;8(6):887-92. doi: 10.1016/j.intimp.2008.01.034. Epub 2008 Mar 7.
10
Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein.用70kd或90kd人热休克蛋白进行DNA疫苗接种对佐剂诱导性关节炎的抑制作用：与60kd热休克蛋白的免疫交叉调节
Arthritis Rheum. 2004 Nov;50(11):3712-20. doi: 10.1002/art.20635.

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The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell-mediated transplant rejection.抑制性受体唾液酸结合免疫球蛋白样凝集素E（Siglec-E）控制抗原呈递细胞的激活和T细胞介导的移植排斥反应。
Sci Transl Med. 2025 May 7;17(797):eads2694. doi: 10.1126/scitranslmed.ads2694.
2
Heat shock protein 70 protects the lungs from hyperoxic injury in a neonatal rat model of bronchopulmonary dysplasia.热休克蛋白 70 可保护支气管肺发育不良新生大鼠模型的肺免受高氧损伤。
PLoS One. 2023 May 18;18(5):e0285944. doi: 10.1371/journal.pone.0285944. eCollection 2023.
3
Exercise duration modulates upper and lower respiratory fluid cellularity, antiviral activity, and lung gene expression.运动时间调节上呼吸道和下呼吸道的液体积聚、抗病毒活性和肺部基因表达。
Physiol Rep. 2021 Oct;9(20):e15075. doi: 10.14814/phy2.15075.
4
L-Citrulline Influences the Body Temperature, Heat Shock Response and Nitric Oxide Regeneration of Broilers Under Thermoneutral and Heat Stress Condition.L-瓜氨酸对热中性和热应激条件下肉鸡的体温、热休克反应及一氧化氮再生的影响。
Front Physiol. 2021 Aug 11;12:671691. doi: 10.3389/fphys.2021.671691. eCollection 2021.

本文引用的文献

1
A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use.一种基于热休克蛋白 70 的疫苗，具有增强的免疫原性，可用于临床。
J Immunol. 2010 Jan 1;184(1):488-96. doi: 10.4049/jimmunol.0902255. Epub 2009 Nov 30.
2
Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases.应激、热休克蛋白与自身免疫：如何利用针对热休克蛋白的免疫反应来控制慢性炎症性疾病。
Ann N Y Acad Sci. 2007 Oct;1113:217-37. doi: 10.1196/annals.1391.020. Epub 2007 Jun 21.
3
Protein misassembly: macromolecular crowding and molecular chaperones.蛋白质错误组装：大分子拥挤与分子伴侣
Adv Exp Med Biol. 2007;594:1-13. doi: 10.1007/978-0-387-39975-1_1.
4
Heat-shock proteins induce T-cell regulation of chronic inflammation.热休克蛋白诱导T细胞对慢性炎症的调节。
Nat Rev Immunol. 2005 Apr;5(4):318-30. doi: 10.1038/nri1593.
5
Heat shock protein-based novel immunotherapies.
Drug News Perspect. 2000 Nov;13(9):517-22. doi: 10.1358/dnp.2000.13.9.858479.
6
Immunization with tumor-derived ER chaperone grp170 elicits tumor-specific CD8+ T-cell responses and reduces pulmonary metastatic disease.用肿瘤来源的内质网伴侣蛋白grp170进行免疫可引发肿瘤特异性CD8 + T细胞反应，并减少肺转移性疾病。
Int J Cancer. 2003 Jun 10;105(2):226-31. doi: 10.1002/ijc.11058.
7
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.热休克蛋白70（HSP70）通过一种依赖于CD14的途径刺激细胞因子的产生，这表明了它作为伴侣蛋白和细胞因子的双重作用。
Nat Med. 2000 Apr;6(4):435-42. doi: 10.1038/74697.
8
The heat-shock proteins.热休克蛋白
Annu Rev Genet. 1988;22:631-77. doi: 10.1146/annurev.ge.22.120188.003215.

Editorial: HSPs-Ambiguous Mediators of Immunity.

作者信息

Calderwood Stuart K, Murshid Ayesha, Borges Thiago J

机构信息

Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA , USA.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

出版信息

Front Immunol. 2016 Dec 26;7:639. doi: 10.3389/fimmu.2016.00639. eCollection 2016.

DOI:10.3389/fimmu.2016.00639
PMID:28082978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5183631/
Abstract
摘要