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[银屑病关节炎:药物治疗选择及给药特点概述]

[Psoriatic arthritis : Overview of drug therapy options and administration characteristics].

作者信息

Behrens F, Thaçi D, Wollenhaupt J, Krüger K

机构信息

CIRI/Rheumatologie und Fraunhofer IME, Translationale Medizin und Pharmakologie, Universitätsklinikum Goethe Universität Frankfurt, Frankfurt am Main, Deutschland.

Exzellenzzentrum Entzündungsmedizin, UKSH - Campus Lübeck, Lübeck, Deutschland.

出版信息

Hautarzt. 2017 Feb;68(2):153-169. doi: 10.1007/s00105-016-3925-9.

Abstract

Psoriatic arthritis is a chronic inflammatory disease of the musculoskeletal system with association to skin psoriasis and is characterized by variable clinical symptoms with very heterogeneous degrees of disease suffering for patients. Clinical manifestations essentially include alterations to the skin and nails, peripheral arthritis, enthesitis, dactylitis and/or spinal involvement. This variability necessitates an individualized therapy of patients with different therapy targets. Apart from international guidelines no therapy recommendations are available in Germany for treatment of psoriatic arthritis. For this reason this article summarizes the established points, characteristics and aspects to be considered in the therapy of psoriatic arthritis in Germany, taking the various main forms of the disease into consideration.

摘要

银屑病关节炎是一种与皮肤银屑病相关的肌肉骨骼系统慢性炎症性疾病,其临床症状多样,患者的疾病痛苦程度差异很大。临床表现主要包括皮肤和指甲改变、外周关节炎、肌腱端炎、指(趾)炎和/或脊柱受累。这种变异性使得针对不同治疗目标的患者需要进行个体化治疗。除国际指南外,德国没有针对银屑病关节炎治疗的治疗建议。因此,本文考虑到该疾病的各种主要形式,总结了德国银屑病关节炎治疗中已确立的要点、特征和需要考虑的方面。

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