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[痴呆的药物治疗]

[Drug treatment of dementia].

作者信息

Kraft J W

机构信息

Fachklinik für Geriatrie und Rehabilitation, Regiomed Klinikum Coburg, Ketschendorfer Str. 33, 96450, Coburg, Deutschland.

出版信息

Internist (Berl). 2017 Feb;58(2):117-124. doi: 10.1007/s00108-016-0180-1.

DOI:10.1007/s00108-016-0180-1
PMID:28083598
Abstract

The number of patients with dementia continues to increase worldwide, mainly due to the demographic developments. Early diagnosis and individualized therapy offers the chance of healing in secondary dementias. The therapy of the more common primary neurodegenerative forms is able to improve the course of the disease. As part of a multimodal management the therapy of dementias includes pharmacological treatment, nondrug treatment strategies, and psychosocial interventions. The treatment is administered depending on dementia form and stage. Antidementive medication and differentiated pharmacological therapy of frequent mental and behavioral symptoms corresponding to current guidelines contribute decisively to stabilize quality of life and activities of daily living, delaying the progression, and thus improving the care situation of patients and caregivers.

摘要

全球痴呆症患者数量持续增加,主要归因于人口结构变化。早期诊断和个体化治疗为继发性痴呆症带来治愈的机会。对于更常见的原发性神经退行性痴呆症形式,其治疗能够改善疾病进程。作为多模式管理的一部分,痴呆症治疗包括药物治疗、非药物治疗策略和心理社会干预。治疗根据痴呆症的类型和阶段进行。按照现行指南使用抗痴呆药物以及对常见精神和行为症状进行差异化药物治疗,对于稳定生活质量和日常生活活动、延缓疾病进展并进而改善患者及护理人员的照护状况具有决定性作用。

相似文献

1
[Drug treatment of dementia].[痴呆的药物治疗]
Internist (Berl). 2017 Feb;58(2):117-124. doi: 10.1007/s00108-016-0180-1.
2
[Antidementia drugs].[抗痴呆药物]
Ther Umsch. 2009 Jun;66(6):432-40. doi: 10.1024/0040-5930.66.6.432.
3
[Cholesterol inhibitor and memantine in symptomatic dementia therapy].[胆固醇抑制剂和美金刚在有症状痴呆治疗中的应用]
Praxis (Bern 1994). 2013 Feb 27;102(5):293-300; discussion 298-9. doi: 10.1024/1661-8157/a001209.
4
Treatment of Alzheimer disease.阿尔茨海默病的治疗。
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[Current antidementive therapy].[当前的抗痴呆治疗]
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[Consensus statement "Dementia 2010" of the Austrian Alzheimer Society].[奥地利阿尔茨海默病协会《2010年痴呆症共识声明》]
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Drugs for cognitive loss and dementia.用于认知功能减退和痴呆的药物。
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When should drug treatment be started for people with dementia?痴呆症患者应何时开始药物治疗?
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9
[Starting Alzheimer therapy in early stages whenever possible. Activities of daily living remain intact longer].尽可能在早期阶段开始阿尔茨海默病治疗。日常生活活动能力保持完好的时间更长。
MMW Fortschr Med. 2002 May 16;144(20):36-9.
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Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.美金刚与胆碱酯酶抑制剂联合用于痴呆治疗的耐受性
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引用本文的文献

1
Dementia in health claims data: The influence of different case definitions on incidence and prevalence estimates.健康声明数据中的痴呆症:不同病例定义对发病率和患病率估计的影响。
Int J Methods Psychiatr Res. 2023 Jun;32(2):e1947. doi: 10.1002/mpr.1947. Epub 2022 Sep 27.
2
[Drug treatment of Alzheimer's dementia : Status quo and perspectives].[阿尔茨海默病痴呆的药物治疗:现状与展望]
Internist (Berl). 2019 Jul;60(7):761-768. doi: 10.1007/s00108-019-0625-4.

本文引用的文献

1
Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments.痴呆症中的淡漠:近期药物治疗相关证据的系统评价。
Curr Psychiatry Rep. 2016 Nov;18(11):103. doi: 10.1007/s11920-016-0737-7.
2
Drug development in Alzheimer's disease: the path to 2025.阿尔茨海默病的药物研发:通向2025年之路
Alzheimers Res Ther. 2016 Sep 20;8:39. doi: 10.1186/s13195-016-0207-9.
3
Interventions to delay functional decline in people with dementia: a systematic review of systematic reviews.延缓痴呆症患者功能衰退的干预措施:系统评价的系统综述
BMJ Open. 2016 Apr 27;6(4):e010767. doi: 10.1136/bmjopen-2015-010767.
4
Ginkgo Biloba for Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.银杏叶治疗轻度认知障碍和阿尔茨海默病:随机对照试验的系统评价和荟萃分析
Curr Top Med Chem. 2016;16(5):520-8. doi: 10.2174/1568026615666150813143520.
5
Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials.银杏叶提取物EGb 761®治疗痴呆症的疗效和耐受性:随机安慰剂对照试验的系统评价和荟萃分析
Clin Interv Aging. 2014 Nov 28;9:2065-77. doi: 10.2147/CIA.S72728. eCollection 2014.
6
Pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease: a systematic review and meta-analysis.阿尔茨海默病神经精神症状的药物治疗:系统评价和荟萃分析。
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Antidepressants for depression in patients with dementia: a review of the literature.用于治疗痴呆患者抑郁症的抗抑郁药:文献综述
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Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014.从 1984 年到 2014 年对阿尔茨海默病的临床试验和后期药物开发的评价。
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[Prevalence of dementia and medical care in German nursing homes: a nationally representative survey].[德国养老院中痴呆症的患病率及医疗护理情况:一项全国代表性调查]
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10
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