Asiedu Bernice, Anang Yvonne, Nyarko Adraina, Doku Derek Amartey, Amoah Brodrick Y, Santa Sheila, Ngala Robert A, Asare George A
a Department of Medical Laboratory Sciences , University of Ghana School of Biomedical and Allied Health Sciences , Korle Bu , Accra , Ghana and.
b Department of Molecular Medicine , Kwame Nkrumah University of Science and Technology , Kumasi , Ghana.
Aging Male. 2017 Mar;20(1):17-22. doi: 10.1080/13685538.2016.1272101. Epub 2017 Jan 13.
The etiology of benign prostatic hyperplasia (BPH) remains a mystery to scientists; estrogen/androgen imbalance in aged men has been implicated.
Thirty (30) apparently healthy men and newly diagnosed BPH patients were recruited from the Ghana Police Hospital. Lower urinary tract syndrome (LUTS) and prostate volume were assessed via the prostate symptom score sheet (IPSS) and abdominopelvic scan, respectively. Laboratory assays for total prostate specific antigen (tPSA) and hormones [androstenedione (AED), testosterone (T), dihydrotestosterone (DHT), androstanedioladiol (3α-adiol), androstanediol (3β-diol), estrone (E1) and estradiol (E2)] were performed via ELISA techniques. Non-parametric analyses were employed. p < 0.05 was considered significant.
AED was significantly higher in controls compared to the BPH patients. AKRIC2 (3α-diol/DHT) was significantly higher in the BPH group (p < 0.001) whiles AKRIC1 (3β-diol/DHT) was significantly lower. Estradiol was significantly higher in BPH (p= 0.029). Age correlated negatively with T, while a negative correlation was observed between TIPSS and 3β-diol and AKRIC1. Also, prostate volume correlated negatively with fT.tPSA correlated positively with E2 and aromatase activity (E2/T) and negatively with fT. On multiple linear regression, DHT and 3β-diol remained independent predictors for TIPSS and fT for tPSA.
Estrogens and androstanediols seem to play a role in BPH development.
良性前列腺增生（BPH）的病因对科学家来说仍是个谜；老年男性体内雌激素/雄激素失衡被认为与之有关。
从加纳警察医院招募了30名表面健康的男性和新诊断的BPH患者。分别通过前列腺症状评分表（IPSS）和腹部盆腔扫描评估下尿路综合征（LUTS）和前列腺体积。采用酶联免疫吸附测定（ELISA）技术对总前列腺特异性抗原（tPSA）和激素[雄烯二酮（AED）、睾酮（T）、双氢睾酮（DHT）、3α-雄烷二醇（3α-二醇）、3β-雄烷二醇（3β-二醇）、雌酮（E1）和雌二醇（E2）]进行实验室检测。采用非参数分析。p < 0.05被认为具有统计学意义。
与BPH患者相比，对照组的AED显著更高。BPH组的AKRIC2（3α-二醇/DHT）显著更高（p < 0.001），而AKRIC1（3β-二醇/DHT）显著更低。BPH患者的雌二醇显著更高（p = 0.029）。年龄与T呈负相关，而TIPSS与3β-二醇和AKRIC1之间呈负相关。此外，前列腺体积与游离睾酮（fT）呈负相关。tPSA与E2和芳香化酶活性（E2/T）呈正相关，与fT呈负相关。在多元线性回归分析中，DHT和3β-二醇仍然是TIPSS和tPSA的fT的独立预测因子。
雌激素和雄烷二醇似乎在BPH的发展中起作用。
