Department of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, LA 70121.
The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA 70121.
Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.TNMI7-0020-2016.
Tuberculous otitis media and mastoiditis, or tuberculous otomastoiditis, is a rare but well-described infectious process occasionally affecting individuals in the United States but more frequently seen in countries where tuberculosis is endemic. Infection may be primary and occur through mucus aspirated through the Eustachian tube. Alternatively, organisms may secondarily infect the nasopharynx when expectorated from the lungs and, less frequently, may be hematogenously spread. Chronic otorrhea and hearing loss are common symptoms, and extensive perforation of the tympanic membranes and facial nerve paralysis are routinely described. Diagnosis is made by direct culture of Mycobacterium tuberculosis, although more recently, molecular techniques have been used. Successful treatment of tuberculous otomastoiditis routinely involves surgical intervention combined with prolonged antituberculosis therapy.
结核性中耳炎和乳突炎,又称结核性耳-乳突炎,是一种罕见但特征明确的感染性疾病,偶发于美国人群,但在结核病流行的国家更为常见。感染可能是原发性的,通过咽鼓管吸入的黏液引起。或者,当从肺部咳出时,病原体可能会继发感染鼻咽部,且较少见的情况下,病原体可能会血行播散。慢性耳漏和听力损失是常见的症状,鼓膜广泛穿孔和面神经麻痹是常见的表现。诊断方法是直接培养结核分枝杆菌,尽管最近也采用了分子技术。结核性耳-乳突炎的成功治疗通常需要手术干预和长期抗结核治疗。