Lim Sungsu, Haque Md Mamunul, Su Dongdong, Kim Dohee, Lee Jun-Seok, Chang Young-Tae, Kim Yun Kyung
Korea Institute of Science and Technology (KIST), Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Seoul 136-791, South Korea.
Chem Commun (Camb). 2017 Feb 4;53(10):1607-1610. doi: 10.1039/c6cc08826k. Epub 2017 Jan 13.
Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
tau聚集体的神经元积累是多种神经退行性疾病（统称为tau蛋白病）的病理标志。一种能够监测神经元中异常tau聚集的tau聚集传感器将有助于tau聚集过程的研究以及tau聚集阻滞剂的发现。在此，我们描述了一种BODIPY荧光传感器（BD-tau），它能选择性地响应活细胞中的病理性tau聚集体。
