Ren Lei, Teng Mujian, Zhang Tao, Zhang Xiaoqing, Sun Bo, Qin Shengying, Zhong Lin, Peng Zhihai, Fan Junwei
Department of Hepatobiliary Pancreatic Surgery, Shandong Qianfoshan Hospital, Shandong University, Jinan 250014, China.
Department of Hepatobiliary Pancreatic Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China.
Pharmacogenomics. 2017 Feb;18(3):265-275. doi: 10.2217/pgs-2016-0098. Epub 2017 Jan 13.
Flavin-containing monooxygenase (FMO) variants were potentially involved in tacrolimus metabolism in kidney transplantion. The influences of FMO3 genotypes on tacrolimus elimination in Chinese liver transplant patients remained unclear.
PATIENTS & METHODS: FMO3 SNPs and CYP3A5 rs776746 were analyzed in 110 Chinese patients.
Donor FMO3 rs1800822 allele T and rs909530 allele T were associated with fast tacrolimus elimination. Combination of polymorphisms of donor FMO3 rs1800822 and rs909530 genotype impacted on tacrolimus elimination (p = 0.0221). The number of donor rs1800822 allele T and rs909530 allele T was confirmed to be an independent predictor of the tacrolimus concentration-to-dose ratios for weeks 2, 3 and 4 in the multivariate analysis.
Donor's FMO3 polymorphisms might affect tacrolimus elimination.
含黄素单加氧酶（FMO）变体可能参与肾移植中他克莫司的代谢。FMO3基因型对中国肝移植患者他克莫司清除率的影响尚不清楚。
对110例中国患者的FMO3单核苷酸多态性（SNP）和CYP3A5 rs776746进行分析。
供体FMO3 rs1800822等位基因T和rs909530等位基因T与他克莫司快速清除相关。供体FMO3 rs1800822和rs909530基因型的多态性组合对他克莫司清除有影响（p = 0.0221）。在多变量分析中，供体rs1800822等位基因T和rs909530等位基因T的数量被证实是第2、3和4周他克莫司浓度与剂量比值的独立预测因子。
供体的FMO3多态性可能影响他克莫司的清除。
