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HCV intergenotype 2k/1b recombinant detected in a DAA-treated patient in Italy.

作者信息

Paolucci Stefania, Premoli Marta, Ludovisi Serena, Mondelli Mario U, Baldanti Fausto

机构信息

Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Division of Infectious Diseases and Immunology, Department of Medical Sciences and Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

出版信息

Antivir Ther. 2017;22(4):365-368. doi: 10.3851/IMP3130. Epub 2017 Jan 13.

DOI:10.3851/IMP3130
PMID:28085002
Abstract

Direct-acting antiviral (DAA) combinations are potent and effective drugs currently recommended for treatment of chronic HCV infection. Difficult to treat genotypes are the most important predictors of treatment failure. We report a case of DAA treatment failure in an HCV-infected patient carrying a recombinant genotype 2k/1b. This strain, first isolated from a Russian patient in 2002, has now been observed for the first time in Italy.

摘要

相似文献

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First identification of a recombinant form of hepatitis C virus in Austrian patients by full-genome next generation sequencing.
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PLoS One. 2017 Jul 25;12(7):e0181273. doi: 10.1371/journal.pone.0181273. eCollection 2017.