静脉注射免疫球蛋白治疗慢性炎症性脱髓鞘性多发性神经病后时空步态参数的变化
Changes in spatiotemporal gait parameters following intravenous immunoglobulin treatment for chronic inflammatory demyelinating polyneuropathy.
作者信息
Vo Mary L, Chin Russell L, Miranda Caroline, Latov Norman
机构信息
Peripheral Neuropathy Center, Weill Cornell Medical College, 1305 York Avenue, 2nd Floor, New York, New York, 10021, USA.
Department of Neurology, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York, USA.
出版信息
Muscle Nerve. 2017 Oct;56(4):732-736. doi: 10.1002/mus.25553. Epub 2017 Mar 24.
INTRODUCTION
Gait impairment is a common presenting symptom in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). However, gait parameters have not previously been evaluated in detail as potential independent outcome measures.
METHODS
We prospectively measured changes in spatiotemporal gait parameters of 20 patients with CIDP at baseline and following treatment with intravenous immunoglobulin (IVIG), using GAITRite® a computerized walkway system with embedded sensors.
RESULTS
Overall, study patients showed significant improvements in gait velocity, cadence, stride length, double support time, stance phase, and swing phase following IVIG treatment. Mean changes in velocity, stance phase, and swing phase, exhibited the greatest statistical significance among the subgroup that exhibited clinically meaningful improvement in Inflammatory Neuropathy Cause and Treatment disability score, Medical Research Council sum score, and grip strength.
CONCLUSIONS
Assessment of gait parameters, in particular velocity, step phase and swing phase, is a potentially sensitive outcome measure for evaluating treatment response in CIDP. Muscle Nerve 56: 732-736, 2017.
引言
步态障碍是慢性炎症性脱髓鞘性多发性神经病（CIDP）患者常见的症状表现。然而，此前尚未将步态参数作为潜在的独立疗效指标进行详细评估。
方法
我们前瞻性地测量了20例CIDP患者在基线时以及接受静脉注射免疫球蛋白（IVIG）治疗后的时空步态参数变化，使用的是带有嵌入式传感器的GAITRite®计算机化步道系统。
结果
总体而言，研究患者在接受IVIG治疗后，步态速度、步频、步幅、双支撑时间、站立期和摆动期均有显著改善。在炎症性神经病病因与治疗残疾评分、医学研究委员会总分和握力方面表现出具有临床意义改善的亚组中，速度、站立期和摆动期的平均变化具有最大的统计学意义。
结论
评估步态参数，尤其是速度、步期和摆动期，是评估CIDP治疗反应的潜在敏感疗效指标。《肌肉与神经》56: 732 - 736, 2017年。
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