Zhao SiWei, Tao Wei, He QiaoZhi, Zhao Hui, Yang HongWei
Appl Opt. 2017 Jan 10;56(2):193-199. doi: 10.1364/AO.56.000193.
Noninvasive blood glucose determination has received considerable attention in the past from both patients and scientists all over the world, and it is becoming increasingly important as a research focus. The two most difficult problems leading to no breakthrough in this area are sensitivity and specificity in determination. In order to obtain reliable measurement results of blood glucose levels, we propose a new liquid photoacoustic resonance theory that can significantly enhance the intensity of the signal and improve the sensitivity. This paper demonstrates the theory of liquid photoacoustic resonance, gives a rigorous mathematical expression, and analyzes the variation of the transducer output in the case of liquid photoacoustic resonance. A signal processing method is demonstrated at the same time under the liquid photoacoustic resonance condition. Meanwhile, the feasibility and validity are verified by experiments with different concentrations of glucose solution. The result shows that liquid photoacoustic resonance can strengthen the signal, and the resolution achieves 20 mg/dL. This method overcomes the issue of low sensitivity and the inaccurate detection in the nonresonant case, and gets accurate results. This result could provide a theoretical basis for realization of noninvasive measurement of blood glucose.
无创血糖测定在过去受到了全球患者和科学家的广泛关注，并且作为一个研究重点正变得越来越重要。导致该领域没有突破的两个最困难的问题是测定的灵敏度和特异性。为了获得可靠的血糖水平测量结果，我们提出了一种新的液体光声共振理论，该理论可以显著增强信号强度并提高灵敏度。本文阐述了液体光声共振理论，给出了严格的数学表达式，并分析了在液体光声共振情况下换能器输出的变化。同时展示了在液体光声共振条件下的一种信号处理方法。此外，通过不同浓度葡萄糖溶液的实验验证了其可行性和有效性。结果表明，液体光声共振可以增强信号，分辨率达到20mg/dL。该方法克服了非共振情况下灵敏度低和检测不准确的问题，并获得了准确的结果。这一结果可为实现无创血糖测量提供理论依据。
