Tachibana K, Okada K, Kobayashi R, Ishihara Y
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:6477-6480. doi: 10.1109/EMBC.2016.7592212.
We describe the possibility of high-sensitivity noninvasive blood glucose measurement based on photoacoustic spectroscopy (PAS). The demand for noninvasive blood glucose-level measurement has increased due to the explosive increase in diabetic patients. We have developed a noninvasive blood glucose-level measurement based on PAS. The conventional method uses a straight-type resonant cell. However, the cell volume is large, which results in a low detection sensitivity and difficult portability. In this paper, a small-sized Helmholtz-type resonant cell is proposed to improve detection sensitivity and portability by reducing the cell dead volume. First, the acoustic property of the small-sized Helmholtz-type resonant cell was evaluated by performing an experiment using a silicone rubber. As a result, the detection sensitivity of the small-sized Helmholtz-type resonant cell was approximately two times larger than that of the conventional straight-type resonant cell. In addition, the inside volume was approximately 30 times smaller. Second, the detection limits of glucose concentration were estimated by performing an experiment using glucose solutions. The experimental results showed that a glucose concentration of approximately 1% was detected by the small-sized Helmholtz-type resonant cell. Although these results on the sensitivity of blood glucose-level measurement are currently insufficient, they suggest that miniaturization of a resonance cell is effective in the application of noninvasive blood glucose-level measurement.
我们描述了基于光声光谱法（PAS）进行高灵敏度无创血糖测量的可能性。由于糖尿病患者数量的急剧增加，对无创血糖水平测量的需求也随之增长。我们已开发出一种基于PAS的无创血糖水平测量方法。传统方法使用的是直管型共振池。然而，该共振池体积较大，导致检测灵敏度较低且便携性差。在本文中，我们提出了一种小型亥姆霍兹型共振池，通过减少池内死体积来提高检测灵敏度和便携性。首先，使用硅橡胶进行实验，对小型亥姆霍兹型共振池的声学特性进行了评估。结果表明，小型亥姆霍兹型共振池的检测灵敏度约为传统直管型共振池的两倍。此外，其内部体积约为传统共振池的三十分之一。其次，使用葡萄糖溶液进行实验，估算了葡萄糖浓度的检测限。实验结果表明，小型亥姆霍兹型共振池能够检测到浓度约为1%的葡萄糖。虽然目前这些关于血糖水平测量灵敏度的结果还不够充分，但它们表明共振池的小型化在无创血糖水平测量的应用中是有效的。
