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心肌收缩储备:一个古老的转变,在现代心力衰竭时代构成一个可靠指标。

Myocardial inotropic reserve: An old twist that constitutes a reliable index in the modern era of heart failure.

作者信息

Parthenakis Fragkiskos, Maragkoudakis Spyridon, Marketou Maria, Patrianakos Alexandros, Zacharis Evaggelos, Vardas Panos

机构信息

Cardiology Department, Heraklion University Hospital, Greece.

Cardiology Department, Heraklion University Hospital, Greece.

出版信息

Hellenic J Cardiol. 2016 Sep-Oct;57(5):311-314. doi: 10.1016/j.hjc.2016.11.027. Epub 2016 Nov 22.

DOI:10.1016/j.hjc.2016.11.027
PMID:28087308
Abstract

Current national and international guidelines, including those of the European Society of Cardiology, recognize that the assessment of prognosis should be a part of the standard management for patients with chronic heart failure (CHF). However, these same guidelines recognize the inherent difficulty of this process. A variety of factors contribute to this difficulty, including the varying etiology, frequent co-morbidity and, perhaps most importantly, huge inter-individual variability in the disease progression and outcome. Although CHF is chronic, it is also a condition in which significant proportions of patients experience apparently 'sudden' death, which almost certainly contributes to our difficulty in assessing individual patient prognosis. A useful tool for the risk stratification of heart failure patients is dobutamine stress echocardiography (DSE), which determines the myocardial viability in ischemic cardiomyopathy and myocardial contractile reserve in idiopathic cardiomyopathy.

摘要

当前的国内和国际指南,包括欧洲心脏病学会的指南,都认识到预后评估应成为慢性心力衰竭(CHF)患者标准管理的一部分。然而,这些指南也认识到这一过程存在内在困难。多种因素导致了这一困难,包括病因各异、频繁合并症,或许最重要的是,疾病进展和结局存在巨大的个体差异。尽管CHF是一种慢性疾病,但仍有相当比例的患者会出现明显的“猝死”,这几乎肯定增加了我们评估个体患者预后的难度。多巴酚丁胺负荷超声心动图(DSE)是心力衰竭患者风险分层的一种有用工具,它可确定缺血性心肌病中的心肌存活性以及特发性心肌病中的心肌收缩储备。

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Myocardial inotropic reserve: An old twist that constitutes a reliable index in the modern era of heart failure.心肌收缩储备:一个古老的转变,在现代心力衰竭时代构成一个可靠指标。
Hellenic J Cardiol. 2016 Sep-Oct;57(5):311-314. doi: 10.1016/j.hjc.2016.11.027. Epub 2016 Nov 22.
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Assessment of myocardial viability with dobutamine stress echocardiography in patients with ischemic left ventricular dysfunction.缺血性左心室功能不全患者多巴酚丁胺负荷超声心动图评估心肌存活性
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Global myocardial contractile reserve assessed by high-dose dobutamine stress echocardiography predicts response to the cardiac resynchronization therapy.通过高剂量多巴酚丁胺负荷超声心动图评估的整体心肌收缩储备可预测心脏再同步治疗的反应。
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Effect of myocardial ischemia during dobutamine stress echocardiography on cardiac mortality in patients with heart failure secondary to ischemic cardiomyopathy.多巴酚丁胺负荷超声心动图检查期间心肌缺血对缺血性心肌病所致心力衰竭患者心脏死亡率的影响。
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Practice guidance for stress echocardiography.应激超声心动图实践指南。
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Assessment of myocardial ischemia by strain dobutamine stress echocardiography and cardiac magnetic resonance perfusion imaging before and after coronary artery bypass grafting.冠状动脉搭桥术前后通过应变多巴酚丁胺负荷超声心动图和心脏磁共振灌注成像评估心肌缺血情况。
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引用本文的文献

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Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177 (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction.在因未再灌注前壁心肌梗死导致的严重缺血性心肌病小鼠模型中,通过用OLT1177(达潘舒特rile)抑制NLRP3炎性小体来保留收缩储备和舒张功能。
Molecules. 2021 Jun 9;26(12):3534. doi: 10.3390/molecules26123534.
2
Assessment of left ventricular twist by 3D ballistocardiography and seismocardiography compared with 2D STI echocardiography in a context of enhanced inotropism in healthy subjects.在健康受试者增强正性肌力作用的情况下,通过三维心动描记术和地震心动描记术评估左心室扭转与二维应变成像超声心动图的比较。
Sci Rep. 2021 Jan 12;11(1):683. doi: 10.1038/s41598-020-79933-4.