Duggan Sarah, Cummins Wayne, O' Donovan Orla, Hughes Helen, Owens Eleanor
Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
Eur J Pharm Sci. 2017 Mar 30;100:64-78. doi: 10.1016/j.ejps.2017.01.008. Epub 2017 Jan 10.
Mucoadhesion is the process of binding a material to the mucosal layer of the body. Utilising both natural and synthetic polymers, mucoadhesive drug delivery is a method of controlled drug release which allows for intimate contact between the polymer and a target tissue. It has the potential to increase bioavailability, decrease potential side effects and offer protection to more sensitive drugs such as proteins and peptide based drugs. The thiolation of polymers has, in the last number of years, come to the fore of mucoadhesive drug delivery, markedly improving mucoadhesion due to the introduction of free thiol groups onto the polymer backbone while also offering a more cohesive polymeric matrix for the slower and more controlled release of drug. This review explores the concept of mucoadhesion and the recent advances in both the polymers and the methods of thiolation used in the synthesis of mucoadhesive drug delivery devices.
粘膜粘附是将一种材料与身体粘膜层结合的过程。利用天然和合成聚合物，粘膜粘附给药是一种控释给药方法，它能使聚合物与靶组织紧密接触。它有可能提高生物利用度，减少潜在的副作用，并为蛋白质和肽类药物等更敏感的药物提供保护。在过去几年中，聚合物的硫醇化已成为粘膜粘附给药的前沿技术，由于在聚合物主链上引入了游离硫醇基团，显著改善了粘膜粘附，同时还为药物的缓慢和更可控释放提供了更具粘性的聚合物基质。本综述探讨了粘膜粘附的概念以及用于合成粘膜粘附给药装置的聚合物和硫醇化方法的最新进展。
