Hill Spencer, Kleiger Gary
Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, NV, USA.
EMBO J. 2017 Feb 15;36(4):392-393. doi: 10.15252/embj.201696154. Epub 2017 Jan 13.
Occasional auto‐modification of ubiquitin ligases typically leads to their proteasomal destruction, but new findings published in now show that in the case of Rsp5/Nedd4, auto‐ubiquitylation instead triggers oligomerization and concomitant reduction of ligase activity. This novel mechanism therefore creates silenced ligases that remain poised for reactivation.
泛素连接酶偶尔的自身修饰通常会导致它们被蛋白酶体降解，但最近发表的新研究结果表明，对于Rsp5/Nedd4而言，自身泛素化反而会引发寡聚化并同时降低连接酶活性。因此，这种新机制产生了处于沉默状态的连接酶，它们随时准备重新激活。
