临床探究：哪些患有代谢综合征的患者能从二甲双胍治疗中获益？
Clinical Inquiry: Which patients with metabolic syndrome benefit from metformin?
作者信息
Stover Liz, Chi Jessica, Kelsberg Gary, Safranek Sarah
机构信息
Valley Family Medicine Residency, University of Washington at Renton, WA, USA.
University of Washington Health Sciences Library, Seattle, WA, USA.
出版信息
J Fam Pract. 2016 Nov;65(11):832-834.
PMID:28087869
Abstract
In patients with metabolic syndrome who are in the highest-risk quartile for progression to diabetes (predicted mean 3-year risk, 60%), metformin, 850 mg twice daily, reduces the absolute risk by about 20% over a 3-year period. Metformin doesn't reduce the incidence in patients at lower risk of progression.
摘要
在代谢综合征患者中，处于进展为糖尿病最高风险四分位数的患者（预测平均3年风险为60%），二甲双胍每日两次，每次850毫克，在3年期间可使绝对风险降低约20%。二甲双胍不会降低进展风险较低患者的发病率。
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