Norris P G, Morris J, Smith N P, Chu A C, Hawk J L
Institute of Dermatology, St. Thomas' Hospital, London, U.K.
J Am Acad Dermatol. 1989 Nov;21(5 Pt 1):966-71. doi: 10.1016/s0190-9622(89)70284-x.
Photobiologic, histologic, and immunohistochemical findings in 14 patients with chronic actinic dermatitis were compared. Grading of routine histologic features of involved skin demonstrated a spectrum of abnormalities ranging from changes resembling chronic dermatitis to those of cutaneous T cell lymphoma. Immunohistochemical staining showed dermal infiltrates to consist predominantly of T lymphocytes, with a significant trend toward lower CD4+/CD8+ ratios in cases with more florid histologic findings. Circulating CD4+/CD8+ cell ratios were normal in five patients and reduced in one patient. Photosensitivity extending to wavelengths longer than 340 nm was detected in eight patients, but the spectrum of photobiologic abnormality did not appear to correlate with either grading of histologic severity or variation in T cell subsets in lesional skin.
对14例慢性光化性皮炎患者的光生物学、组织学和免疫组化结果进行了比较。对受累皮肤常规组织学特征的分级显示出一系列异常，范围从类似慢性皮炎的改变到皮肤T细胞淋巴瘤的改变。免疫组化染色显示真皮浸润主要由T淋巴细胞组成，在组织学表现更明显的病例中，CD4+/CD8+比值有显著降低的趋势。5例患者循环CD4+/CD8+细胞比值正常，1例降低。8例患者检测到光敏性扩展至波长大于340nm，但光生物学异常谱似乎与组织学严重程度分级或皮损中T细胞亚群的变化均无相关性。
