Ashinoff R, Cohen R, Lipkin G
Department of Dermatology, New York University Medical Center.
J Am Acad Dermatol. 1989 Nov;21(5 Pt 2):1076-80. doi: 10.1016/s0190-9622(89)70299-1.
The rare association of severe erosive lichen planus and Castleman's tumor is presented. Castleman's tumor, or giant lymph node hyperplasia, is a benign neoplasm resembling thymic tumors and is associated with several immunologic abnormalities. Lichen planus also is associated with immunologic defects. One hypothesis linking these two diseases is that lymphocytes may become sensitized to tumor antigens on the Castleman's tumor and attack cross-reacting structures in the skin and other stratified squamous mucosae to produce the clinical picture of lichen planus.
本文报道了严重糜烂性扁平苔藓与Castleman病的罕见关联。Castleman病，即巨大淋巴结增生症，是一种类似胸腺瘤的良性肿瘤，与多种免疫异常有关。扁平苔藓也与免疫缺陷有关。将这两种疾病联系起来的一种假说是，淋巴细胞可能对Castleman病肿瘤上的肿瘤抗原产生致敏，并攻击皮肤和其他复层鳞状黏膜中的交叉反应结构，从而产生扁平苔藓的临床表现。
