Cardiology, University Hospital Rangueil, 31059 Toulouse Cedex 09, France.
INSERM 1048, Toulouse, France.
Europace. 2018 Apr 1;20(4):692-697. doi: 10.1093/europace/euw401.
Very narrow QRS have been reported in sudden death survivors but prevalence and prognosis role of narrow QRS is unknown.
546 healthy men between 50 and 60 years (group 1) and 373 similar patients with coronary artery disease (368 men, group 2) underwent signal averaged ECG (SA-ECG) allowing precise measurement of QRS duration. All cause-mortality was determined after 18 ± 3 years follow-up. Mean QRS duration was 97 ± 13 ms in group 1 and 103 ± 16 ms in group 2. Tenth percentile was 84 ms in group 1 and 85 ms in group 2. All cause-mortality in group 1 was 10.4% (57/546): 6/85 in case of QRS <85 ms (7%) and 2/23 (9%) in case of QRS >120 ms (ns). HR for all-cause mortality was 0.75 (95% CI 0.32-1.76, P = 0.52) for QRS <85 ms and 0.86 (95% CI 0.21-3.53, P = 0.84) for QRS >120 ms. All cause mortality in group 2 was 29% (109/373): 7/44 in case of QRS <85 ms (16%) and 22/44 (50%) in case of QRS >120 ms (P = 0.002). HR for all-cause mortality was 0.65 (95% CI 0.29-1.45, P = 0.29) for QRS <85 ms and 1.73 (95% CI 1.02-2.94, P = 0.05) for QRS >120 ms.
QRS duration <80-85 ms can be observed in a significant proportion of middle-aged healthy males and in similar patients with ischemic heart disease. Narrow QRS were not linked to prognosis in any group.
已有研究报道,在心脏性猝死幸存者中存在非常窄的 QRS 波,但目前尚不清楚 QRS 波变窄的患病率和预后作用。
546 名 50 至 60 岁的健康男性(第 1 组)和 373 名患有冠状动脉疾病的类似患者(368 名男性,第 2 组)接受了信号平均心电图(SA-ECG)检查,可精确测量 QRS 持续时间。在 18±3 年的随访后确定全因死亡率。第 1 组的平均 QRS 持续时间为 97±13ms,第 2 组为 103±16ms。第 1 组的 QRS 波第十个百分位数为 84ms,第 2 组为 85ms。第 1 组的全因死亡率为 10.4%(57/546):QRS<85ms 的有 6/85(7%),QRS>120ms 的有 2/23(9%)(ns)。QRS<85ms 的全因死亡率的 HR 为 0.75(95%CI 0.32-1.76,P=0.52),QRS>120ms 的 HR 为 0.86(95%CI 0.21-3.53,P=0.84)。第 2 组的全因死亡率为 29%(109/373):QRS<85ms 的有 7/44(16%),QRS>120ms 的有 22/44(50%)(P=0.002)。QRS<85ms 的全因死亡率的 HR 为 0.65(95%CI 0.29-1.45,P=0.29),QRS>120ms 的 HR 为 1.73(95%CI 1.02-2.94,P=0.05)。
在相当一部分中年健康男性和患有缺血性心脏病的类似患者中,可观察到 QRS 波持续时间<80-85ms。在任何一组中,窄 QRS 均与预后无关。