衰老造血干细胞区室中DNA损伤的积累。
Accumulation of DNA damage in the aged hematopoietic stem cell compartment.
作者信息
Beerman Isabel
机构信息
Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD.
出版信息
Semin Hematol. 2017 Jan;54(1):12-18. doi: 10.1053/j.seminhematol.2016.11.001. Epub 2016 Nov 18.
Abstract
Aging is associated with loss of functional potential of multiple tissue systems, and there has been significant interest in understanding how tissue-specific cells contribute to this decline. DNA damage accumulation has been widely associated with aging in differentiated cell types. However, tissue-specific stem cells were once thought to be a geno-protected population, as damage accrued in a stem cell population has the potential to be inherited by differentiated progeny, as well as propagated within the stem cell compartment through self-renewal divisions. This review will discuss the evidence for DNA damage accumulation in the aged HSC compartment, potential drivers, and finally the consequences of the acquired damage.
摘要
衰老与多个组织系统功能潜力的丧失相关，人们对了解组织特异性细胞如何导致这种衰退产生了浓厚兴趣。DNA损伤积累已广泛被认为与分化细胞类型的衰老有关。然而，组织特异性干细胞曾被认为是基因保护群体，因为干细胞群体中积累的损伤有可能被分化后代遗传，也有可能通过自我更新分裂在干细胞区室中传播。本综述将讨论老年造血干细胞区室中DNA损伤积累的证据、潜在驱动因素，以及最终获得性损伤的后果。
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