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Accumulation of DNA damage in the aged hematopoietic stem cell compartment.衰老造血干细胞区室中DNA损伤的积累。
Semin Hematol. 2017 Jan;54(1):12-18. doi: 10.1053/j.seminhematol.2016.11.001. Epub 2016 Nov 18.
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DNA-damage-induced differentiation in hematopoietic stem cells.造血干细胞中的 DNA 损伤诱导分化。
Cell. 2012 Mar 2;148(5):847-8. doi: 10.1016/j.cell.2012.02.011.
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Aging of hematopoietic stem cells: DNA damage and mutations?造血干细胞的衰老：DNA 损伤与突变？
Exp Hematol. 2016 Oct;44(10):895-901. doi: 10.1016/j.exphem.2016.06.253. Epub 2016 Jul 8.
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Proliferation: Driver of HSC aging phenotypes?增殖：造血干细胞衰老表型的驱动力？
Mech Ageing Dev. 2020 Oct;191:111331. doi: 10.1016/j.mad.2020.111331. Epub 2020 Aug 14.
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Mechanisms of Hematopoietic Stem Cell Ageing and Targets for Hematopoietic Tumour Prevention.造血干细胞衰老的机制和造血肿瘤预防的靶点。
Adv Exp Med Biol. 2018;1086:117-140. doi: 10.1007/978-981-13-1117-8_8.
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Epigenetic regulation of hematopoietic stem cell aging.造血干细胞衰老的表观遗传调控。
Exp Cell Res. 2014 Dec 10;329(2):192-9. doi: 10.1016/j.yexcr.2014.09.013. Epub 2014 Sep 28.
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DNA Damage Response in Hematopoietic Stem Cell Ageing.造血干细胞衰老过程中的DNA损伤反应
Genomics Proteomics Bioinformatics. 2016 Jun;14(3):147-154. doi: 10.1016/j.gpb.2016.04.002. Epub 2016 May 21.
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MicroRNAs in hematopoietic stem cell aging.造血干细胞衰老中的 microRNAs。
Mech Ageing Dev. 2020 Jul;189:111281. doi: 10.1016/j.mad.2020.111281. Epub 2020 Jun 5.
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The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging.衰老的造血干细胞微环境：导致造血衰老的表型和功能变化及机制
Semin Hematol. 2017 Jan;54(1):25-32. doi: 10.1053/j.seminhematol.2016.10.001. Epub 2016 Oct 19.
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Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence.炎症性活性氧促进范可尼贫血突变并与之协同作用导致造血衰老。
J Cell Sci. 2007 May 1;120(Pt 9):1572-83. doi: 10.1242/jcs.003152. Epub 2007 Apr 3.
引用本文的文献
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Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.减少功能缺陷的衰老造血干细胞可减轻老年受体小鼠的衰老相关表型。
Cell Res. 2025 Jan;35(1):45-58. doi: 10.1038/s41422-024-01057-5. Epub 2025 Jan 2.
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Clonal hematopoiesis and hematological malignancy.克隆性造血与血液系统恶性肿瘤。
J Clin Invest. 2024 Oct 1;134(19):e180065. doi: 10.1172/JCI180065.
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Comparison of genetic and epigenetic profiles of periodontitis according to the presence of type 2 diabetes.根据2型糖尿病的存在情况对牙周炎的基因和表观遗传特征进行比较。
MedComm (2020). 2024 Jun 19;5(7):e620. doi: 10.1002/mco2.620. eCollection 2024 Jul.
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Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells.造血干细胞和祖细胞中嵌合结构变异的细胞类型特异性后果。
Nat Genet. 2024 Jun;56(6):1134-1146. doi: 10.1038/s41588-024-01754-2. Epub 2024 May 28.
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Determinants of mosaic chromosomal alteration fitness.镶嵌染色体改变适应性的决定因素。
Nat Commun. 2024 May 7;15(1):3800. doi: 10.1038/s41467-024-48190-8.
6
Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders.端粒生物学障碍中的适应性和不适应性克隆性造血
Curr Hematol Malig Rep. 2024 Feb;19(1):35-44. doi: 10.1007/s11899-023-00719-2. Epub 2023 Dec 14.
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Hematopoietic Stem Cells and the Immune System in Development and Aging.造血干细胞与免疫系统的发育和衰老。
Int J Mol Sci. 2023 Mar 20;24(6):5862. doi: 10.3390/ijms24065862.
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Molecular Damage in Aging.衰老过程中的分子损伤。
Nat Aging. 2021 Dec;1(12):1096-1106. doi: 10.1038/s43587-021-00150-3. Epub 2021 Dec 20.
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Clonal hematopoiesis: Mutation-specific adaptation to environmental change.克隆性造血：突变特异性适应环境变化。
Cell Stem Cell. 2022 Jun 2;29(6):882-904. doi: 10.1016/j.stem.2022.05.006.
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15-PGDH regulates hematopoietic and gastrointestinal fitness during aging.15-PGDH 调控衰老过程中的造血和胃肠道适应性。
PLoS One. 2022 May 19;17(5):e0268787. doi: 10.1371/journal.pone.0268787. eCollection 2022.
本文引用的文献
1
Tissue-specific mutation accumulation in human adult stem cells during life.人类成体干细胞在生命过程中的组织特异性突变积累。
Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3.
2
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults.携带 AML 相关突变的克隆性造血在健康成年人中普遍存在。
Nat Commun. 2016 Aug 22;7:12484. doi: 10.1038/ncomms12484.
3
Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation.年龄相关的造血干细胞中组蛋白甲基转移酶 SUV39H1 的减少会扰乱异染色质和 B 淋巴细胞分化。
Stem Cell Reports. 2016 Jun 14;6(6):970-984. doi: 10.1016/j.stemcr.2016.05.007.
4
Increased reactive oxygen species and exhaustion of quiescent CD34-positive bone marrow cells may contribute to poor graft function after allotransplants.活性氧增加以及静止CD34阳性骨髓细胞耗竭可能导致同种异体移植后移植物功能不佳。
Oncotarget. 2016 May 24;7(21):30892-906. doi: 10.18632/oncotarget.8810.
5
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.Rad18在体内独立于范可尼贫血途径赋予造血祖细胞DNA损伤耐受性。
Nucleic Acids Res. 2016 May 19;44(9):4174-88. doi: 10.1093/nar/gkw072. Epub 2016 Feb 15.
6
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.天然存在的p16（Ink4a）阳性细胞会缩短健康寿命。
Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.
7
Mosaic 13q14 deletions in peripheral leukocytes of non-hematologic cancer cases and healthy controls.非血液系统癌症病例和健康对照外周血白细胞中的13q14染色体镶嵌缺失。
J Hum Genet. 2016 May;61(5):411-8. doi: 10.1038/jhg.2015.166. Epub 2016 Jan 14.
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Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.干细胞特异性机制确保造血干细胞内及造血干细胞衰老过程中的基因组保真度。
Cell Rep. 2015 Dec 22;13(11):2412-2424. doi: 10.1016/j.celrep.2015.11.030. Epub 2015 Dec 10.
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Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice.活性氧导致老年C57BL/6 J小鼠骨髓造血干细胞功能障碍。
J Biomed Sci. 2015 Oct 24;22:97. doi: 10.1186/s12929-015-0201-8.
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Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions.从端粒长度分布重建造血干细胞的体内动力学。
Elife. 2015 Oct 15;4:e08687. doi: 10.7554/eLife.08687.
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