造血干细胞中的 DNA 损伤诱导分化。

DNA-damage-induced differentiation in hematopoietic stem cells.

机构信息

Department of Stem Cell and Regenerative Biology, Harvard University, Immune Disease Institute, Children's Hospital Boston, Boston, MA 02116, USA.

出版信息

Cell. 2012 Mar 2;148(5):847-8. doi: 10.1016/j.cell.2012.02.011.

DOI:10.1016/j.cell.2012.02.011

PMID:22385954

Abstract

Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.

摘要

造血干细胞（HSCs）的衰老伴随着功能潜力的降低。Wang 等人现在提供了证据，证明转录因子 BATF 介导的 HSC 特异性分化检查点限制了 HSCs 对 DNA 损伤积累的自我更新。