Al Kasab Sami, Cassarly Christy, Le Ngoc-Anh, Martin Renee, Brinley Julia, Chimowitz Marc I, Turan Tanya N
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina.
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina.
J Stroke Cerebrovasc Dis. 2017 Mar;26(3):488-493. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.006. Epub 2017 Jan 6.
Oxidized low-density lipoprotein (OxLDL) is a contributor to atherosclerosis development. OxLDL formation increases in the postprandial state due to oxidative stress in subjects with coronary artery disease (CAD) and diabetes, but has not been studied in patients with atherosclerotic stroke. We aimed to determine differences in postprandial OxLDL in patients with atherosclerotic stroke compared to stroke from other causes.
Patients with ischemic stroke but no history of CAD (n = 42) were enrolled and categorized by stroke subtype as extracranial atherosclerosis (EC), n = 12; intracranial atherosclerosis (IC), n = 16; or other cause, n = 14. After fasting overnight, subjects consumed a standardized fat meal. OxLDL levels were measured at t = 0 and t = 4 hours postprandial using enzyme-linked immunosorbent assay. Comparisons between the mean changes in OxLDL between the groups were performed using the analysis of variance procedure.
The IC group had the highest mean baseline level of OxLDL and the greatest decline during the postprandial period. There was a trend toward a difference in the mean change in OxLDL between the 3 groups (P = .0553). Subjects with atherosclerotic stroke (EC and IC groups) had higher fasting OxLDL and had a significant decline in OxLDL compared to those with stroke from other causes (P = .0164).
Subjects with stroke due to atherosclerosis, particularly intracranially, demonstrated high fasting OxLDL and a decline in OxLDL during the postprandial period. This decline in OxLDL may indicate an accelerated clearance of OxLDL resulting from meal-induced oxidative stress.
氧化型低密度脂蛋白（OxLDL）是动脉粥样硬化发展的一个促成因素。由于冠状动脉疾病（CAD）和糖尿病患者存在氧化应激，餐后状态下OxLDL的形成会增加，但尚未在动脉粥样硬化性卒中患者中进行研究。我们旨在确定动脉粥样硬化性卒中患者与其他原因所致卒中患者餐后OxLDL的差异。
纳入无CAD病史的缺血性卒中患者（n = 42），并根据卒中亚型分为颅外动脉粥样硬化（EC）组，n = 12；颅内动脉粥样硬化（IC）组，n = 16；或其他原因组，n = 14。禁食过夜后，受试者食用标准化脂肪餐。使用酶联免疫吸附测定法在餐后0小时和4小时测量OxLDL水平。采用方差分析程序对各组之间OxLDL的平均变化进行比较。
IC组的OxLDL平均基线水平最高，且餐后期间下降幅度最大。三组之间OxLDL的平均变化存在差异趋势（P = 0.0553）。动脉粥样硬化性卒中患者（EC组和IC组）的空腹OxLDL水平较高，与其他原因所致卒中患者相比，OxLDL有显著下降（P = 0.0164）。
动脉粥样硬化所致卒中患者，尤其是颅内动脉粥样硬化患者，表现出空腹OxLDL水平较高，且餐后期间OxLDL下降。OxLDL的这种下降可能表明膳食诱导的氧化应激导致OxLDL清除加速。
