Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
Departamento de Biología Funcional, Inmunología, Facultad de Medicina, IUOPA, Universidad de Oviedo, 33006 Oviedo, Spain.
Trends Immunol. 2017 Mar;38(3):151-153. doi: 10.1016/j.it.2016.12.005. Epub 2017 Jan 11.
Natural killer (NK) cells are alerted to infected and transformed cells by local upregulation of ligands for the NK-activating receptor NKG2D. In a recent report, Greene et al. unveil a new mechanism that induces the expression of the NKG2D ligand retinoic acid early-inducible (RAE-1) in response to murine cytomegalovirus (MCMV) infection through inhibition of casein kinase 2 (CK2), an activator of the repressor histone deacetylase HDAC3.
自然杀伤 (NK) 细胞通过局部上调 NK 激活受体 NKG2D 的配体来识别感染和转化的细胞。在最近的一份报告中，Greene 等人揭示了一种新的机制，该机制通过抑制激活组蛋白去乙酰化酶 HDAC3 的蛋白激酶 2 (CK2)，诱导 NKG2D 配体视黄酸早期诱导 (RAE-1) 的表达，以响应小鼠巨细胞病毒 (MCMV) 感染。
