Distant spread of a supratentorial glioblastoma to the spinal cord.

作者信息

Ravindran Krishnan, Gaillard Frank, Lasocki Arian

机构信息

Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia.

Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Radiology, The University of Melbourne, Parkville, VIC, Australia.

出版信息

J Clin Neurosci. 2017 Apr;38:56-57. doi: 10.1016/j.jocn.2016.11.010. Epub 2017 Jan 12.

DOI:10.1016/j.jocn.2016.11.010

PMID:28089418

Abstract

Extracranial spread from a glioblastoma is rare. We present a case of a 48year-old man with a previously radiologically-stable left temporal lobe glioblastoma presenting with symptoms referrable to the spinal cord. MRI revealed a spinal cord lesion, with the differential including transverse myelitis and tumour. Open surgical biopsy revealed high-grade astrocytoma. Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour.

摘要