通过分析斑马鱼幼体中生物标志物基因表达评估微塑料吸附污染物的生物有效性。
Assessment of microplastic-sorbed contaminant bioavailability through analysis of biomarker gene expression in larval zebrafish.
作者信息
Sleight Victoria A, Bakir Adil, Thompson Richard C, Henry Theodore B
机构信息
School of Marine Science and Engineering, Marine Biology and Ecology Research Centre, University of Plymouth, Plymouth PL4 8AA, UK; British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, Cambridge, CB3 0ET, UK; Institute of Life and Earth Sciences, School of Energy, Geoscience, Infrastructure and Society, Heriot-Watt University, Edinburgh EH14 4AS, UK.
School of Marine Science and Engineering, Marine Biology and Ecology Research Centre, University of Plymouth, Plymouth PL4 8AA, UK; Petroleum and Environmental Geochemistry Group, School of Geography Earth and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth, Devon PL4 8AA, UK; School of Earth & Environmental Sciences, University of Portsmouth, Burnaby Road, Portsmouth PO1 3QL, UK.
出版信息
Mar Pollut Bull. 2017 Mar 15;116(1-2):291-297. doi: 10.1016/j.marpolbul.2016.12.055. Epub 2017 Jan 12.
Microplastics (MPs) are prevalent in marine ecosystems. Because toxicants (termed here "co-contaminants") can sorb to MPs, there is potential for MPs to alter co-contaminant bioavailability. Our objective was to demonstrate sorption of two co-contaminants with different physicochemistries [phenanthrene (Phe), logK=4.57; and 17α-ethinylestradiol (EE2), logK=3.67] to MPs; and assess whether co-contaminant bioavailability was increased after MP settlement. Bioavailability was indicated by gene expression in larval zebrafish. Both Phe and EE2 sorbed to MPs, which reduced bioavailability by a maximum of 33% and 48% respectively. Sorption occurred, but was not consistent with predictions based on co-contaminant physicochemistry (Phe having higher logK was expected to have higher sorption). Contaminated MPs settled to the bottom of the exposures did not lead to increased bioavailability of Phe or EE2. Phe was 48% more bioavailable than predicted by a linear sorption model, organism-based measurements therefore contribute unique insight into MP co-contaminant bioavailability.
微塑料（MPs）在海洋生态系统中普遍存在。由于有毒物质（这里称为“共污染物”）可吸附到微塑料上，微塑料有可能改变共污染物的生物利用度。我们的目标是证明两种具有不同物理化学性质的共污染物[菲（Phe），logK = 4.57；和17α-乙炔雌二醇（EE2），logK = 3.67]对微塑料的吸附；并评估微塑料沉降后共污染物的生物利用度是否增加。生物利用度通过斑马鱼幼体的基因表达来表示。菲和EE2都吸附到微塑料上，这分别使生物利用度最大降低了33%和48%。吸附确实发生了，但与基于共污染物物理化学性质的预测不一致（预期logK较高的菲具有更高的吸附）。暴露环境底部沉降的受污染微塑料并未导致菲或EE2的生物利用度增加。菲的生物利用度比线性吸附模型预测的高48%，因此基于生物体的测量为微塑料共污染物生物利用度提供了独特的见解。
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