Pinola Pekka, Puukka Katri, Piltonen Terhi T, Puurunen Johanna, Vanky Eszter, Sundström-Poromaa Inger, Stener-Victorin Elisabet, Lindén Hirschberg Angelica, Ravn Pernille, Skovsager Andersen Marianne, Glintborg Dorte, Mellembakken Jan Roar, Ruokonen Aimo, Tapanainen Juha S, Morin-Papunen Laure C
Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland; University of Oulu and Medical Research Center Oulu, Oulu, Finland.
University of Oulu and Medical Research Center Oulu, Oulu, Finland; Nordlab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland.
Fertil Steril. 2017 Mar;107(3):788-795.e2. doi: 10.1016/j.fertnstert.2016.12.017. Epub 2017 Jan 12.
To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life.
Case-control study.
Not applicable.
PATIENT(S): In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years).
INTERVENTIONS(S): None.
MAIN OUTCOME MEASURE(S): Body mass index (BMI), waist circumference, blood pressure, glucose, insulin, cholesterol, lipoproteins, triglycerides and high-sensitivity C-reactive protein.
RESULT(S): Both normo- and hyperandrogenic women with PCOS were more obese, especially abdominally. They had increased serum levels of insulin (fasting and in oral glucose tolerance tests), triglycerides, low-density lipoprotein, and total cholesterol, higher blood pressure, and lower high-density lipoprotein levels independently from BMI compared with the control population as early as from young adulthood until menopause. The prevalence of metabolic syndrome was two- to fivefold higher in women with PCOS compared with control women, depending on age and phenotype, and the highest prevalence was observed in hyperandrogenic women with PCOS at late reproductive age.
CONCLUSION(S): When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.
比较患有多囊卵巢综合征（PCOS）的雄激素正常和高雄激素女性与处于生殖期不同年龄段的对照女性的代谢谱。
病例对照研究。
不适用。
总共1550名患有雄激素正常（n = 686）或高雄激素（n = 842）PCOS的女性以及447名对照女性被分为三个年龄组：<30岁、30 - 39岁和>39岁。
无。
体重指数（BMI）、腰围、血压、血糖、胰岛素、胆固醇、脂蛋白、甘油三酯和高敏C反应蛋白。
患有PCOS的雄激素正常和高雄激素女性均更肥胖，尤其是腹部肥胖。与对照人群相比，早在成年早期直至绝经，她们的胰岛素（空腹及口服葡萄糖耐量试验时）、甘油三酯、低密度脂蛋白和总胆固醇血清水平升高，血压更高，高密度脂蛋白水平更低，且这些情况独立于BMI。PCOS女性代谢综合征的患病率比对照女性高2至5倍，这取决于年龄和表型，且在生殖后期患有PCOS的高雄激素女性中患病率最高。
在评估PCOS女性的代谢风险时，应考虑雄激素状态，尤其是腹部肥胖和年龄，这将有助于从成年早期开始对该综合征进行针对性管理。
