使用 OMERACT 过滤器就全关节置换试验结果报告达成共识：终末期关节炎全髋关节和全膝关节置换试验最终核心领域集的认可。
Achieving Consensus on Total Joint Replacement Trial Outcome Reporting Using the OMERACT Filter: Endorsement of the Final Core Domain Set for Total Hip and Total Knee Replacement Trials for Endstage Arthritis.
机构信息
From the University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center, Birmingham, Alabama; Department of Orthopedics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA; University of Melbourne Department of Surgery, St. Vincent's Hospital, Melbourne, Australia; Department of Orthopedic Surgery and Department of Medicine, University of Arizona, Tucson, Arizona; Weill Cornell Medical School and Hospital for Special Surgery, New York, New York; Healthy Motivation, and Global Alliance for Musculoskeletal Health, the Bone and Joint Decade, Santa Barbara, California, USA; Department of Psychology, Health and Technology, University of Twente, Enschede, the Netherlands.
J.A. Singh, MBBS, MPH, Professor of Medicine and Epidemiology, University of Alabama at Birmingham and Staff Physician, Birmingham Veterans Affairs Medical Center, and Research Collaborator, Department of Orthopedics, Mayo Clinic College of Medicine; M.M. Dowsey, PhD, National Health and Medical Research Council Clinical Research Fellow, University of Melbourne Department of Surgery, St. Vincent's Hospital; M. Dohm, MD, Assistant Professor, Department of Orthopedic Surgery and Department of Medicine, University of Arizona; S.M. Goodman, MD, Associate Professor of Clinical Medicine, Weill Cornell Medical School and Associate Attending Hospital for Special Surgery; A.L. Leong, MBA, President and CEO, Healthy Motivation, and Director of Strategic Relations, Global Alliance for Musculoskeletal Health, the Bone and Joint Decade; M.M. Scholte Voshaar, PhD, Research Fellow, Department of Psychology, Health and Technology, University of Twente; P.F. Choong, MBBS, MD, FRACS, FAOrthA Professor of Surgery, University of Melbourne, and Head of Department of Surgery, and Director of Orthopedic Surgery, St. Vincent's Hospital.
出版信息
J Rheumatol. 2017 Nov;44(11):1723-1726. doi: 10.3899/jrheum.161113. Epub 2017 Jan 15.
OBJECTIVE
Discussion and endorsement of the OMERACT total joint replacement (TJR) core domain set for total hip replacement (THR) and total knee replacement (TKR) for endstage arthritis; and next steps for selection of instruments.
METHODS
The OMERACT TJR working group met at the 2016 meeting at Whistler, British Columbia, Canada. We summarized the previous systematic reviews, the preliminary OMERACT TJR core domain set and results from previous surveys. We discussed preliminary core domains for TJR clinical trials, made modifications, and identified challenges with domain measurement.
RESULTS
Working group participants (n = 26) reviewed, clarified, and endorsed each of the inner and middle circle domains and added a range of motion domain to the research agenda. TJR were limited to THR and TKR but included all endstage hip and knee arthritis refractory to medical treatment. Participants overwhelmingly endorsed identification and evaluation of top instruments mapping to the core domains (100%) and use of subscales of validated multidimensional instruments to measure core domains for the TJR clinical trial core measurement set (92%).
CONCLUSION
An OMERACT core domain set for hip/knee TJR trials has been defined and we are selecting instruments to develop the TJR clinical trial core measurement set to serve as a common foundation for harmonizing measures in TJR clinical trials.
目的
讨论并认可针对终末期关节炎的全关节置换（TJR）核心领域集，包括全髋关节置换（THR）和全膝关节置换（TKR）；并确定选择工具的下一步措施。
方法
OMERACT TJR 工作组于 2016 年在加拿大不列颠哥伦比亚省惠斯勒举行的会议上进行了会面。我们总结了之前的系统评价、初步的 OMERACT TJR 核心领域集以及之前调查的结果。我们讨论了 TJR 临床试验的初步核心领域，进行了修改，并确定了领域测量的挑战。
结果
工作组参与者（n=26）审查、澄清并认可了内圈和中环领域的每一个领域，并将一个活动范围领域添加到研究议程中。TJR 仅限于 THR 和 TKR，但包括所有对药物治疗有抗药性的终末期髋关节和膝关节关节炎。参与者压倒性地认可了确定和评估与核心领域相对应的顶级工具（100%），并使用多维工具的子量表来测量 TJR 临床试验核心测量集中的核心领域（92%）。
结论
已经定义了髋关节/膝关节 TJR 试验的 OMERACT 核心领域集，我们正在选择工具来开发 TJR 临床试验核心测量集，作为协调 TJR 临床试验措施的共同基础。
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