类风湿关节炎患者人口统计学和临床特征与类风湿因子血清阳性的相关性
Correlation of Demographic and Clinical Characteristics with Rheumatoid Factor Seropositivity in Rheumatoid Arthritis Patients.
作者信息
Othman Maizatul Akmal, Ghazali Wan Syamimee Wan, Yahya Nurul Khaiza, Wong Kah Keng
机构信息
Department of Immunology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Department of Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
出版信息
Malays J Med Sci. 2016 Nov;23(6):52-59. doi: 10.21315/mjms2016.23.6.6. Epub 2016 Dec 7.
BACKGROUND
The rheumatoid factor (RF) blood test is the most commonly adopted test for the diagnosis of rheumatoid arthritis (RA). RA patients who are seropositive for RF might face a greater likelihood of developing more aggressive symptoms.
METHODS
Our goal was to study the demographic and clinical characteristics, as well as their correlation with RF seropositivity, among a series of 80 RA patients aged ≥ 18 years who attend Hospital Universiti Sains Malaysia (HUSM).
RESULTS
Of the 80 RA patients included in this study, 66 (82.5%) were female and 14 (17.5%) were male. No significant associations between RF seropositivity and demographic and/or clinical characteristics or other laboratory investigations were observed, including gender, morning stiffness, individual joint involvement (from multiple sites of the body), and erythrocyte sedimentation rate (ESR) measurement. However, a significant association between RF seropositivity and patients aged ≥ 50 was found ( = 0.032).
CONCLUSION
RF seropositivity was found to be more common in much older RA patients.
背景
类风湿因子（RF）血液检测是诊断类风湿关节炎（RA）最常用的检测方法。RF血清阳性的RA患者可能更有可能出现更严重的症状。
方法
我们的目标是研究马来西亚理科大学医院（HUSM）收治的80例年龄≥18岁的RA患者的人口统计学和临床特征，以及它们与RF血清阳性的相关性。
结果
本研究纳入的80例RA患者中，66例（82.5%）为女性，14例（17.5%）为男性。未观察到RF血清阳性与人口统计学和/或临床特征或其他实验室检查之间存在显著关联，包括性别、晨僵、个体关节受累（来自身体多个部位）和红细胞沉降率（ESR）测量。然而，发现RF血清阳性与年龄≥50岁的患者之间存在显著关联（P = 0.032）。
结论
发现RF血清阳性在年龄较大的RA患者中更为常见。
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