Novey H S, Bernstein I L, Mihalas L S, Terr A I, Yunginger J W
Department of Medicine, University of California, Irvine 92668.
J Allergy Clin Immunol. 1989 Nov;84(5 Pt 2):829-33. doi: 10.1016/0091-6749(89)90347-3.
Sensitization to HMW allergens is a relatively common immunopathogenic factor in occupational asthma. The mechanism of sensitization is an IgE-mediated, type I reaction. High molecular weight allergen refers to proteins and polymers of organic compounds over 5 kd and usually in the 20 to 50 kd range. In most cases diagnosis requires: 1. A high index of suspicion of job-related asthma. 2. Exposure to HMW compounds and clinical findings associated with such an exposure. 3. Confirmation of sensitization by appropriate in vitro or in vivo tests. 4. Confirmation of a pathogenic role by physiologic measurements in either a natural setting or during laboratory-controlled challenges.
对高分子量变应原致敏是职业性哮喘中一种相对常见的免疫致病因素。致敏机制是一种IgE介导的I型反应。高分子量变应原是指分子量超过5kd的蛋白质和有机化合物聚合物，通常在20至50kd范围内。在大多数情况下，诊断需要：1. 高度怀疑与工作相关的哮喘。2. 接触高分子量化合物以及与此类接触相关的临床发现。3. 通过适当的体外或体内试验确认致敏。4. 通过在自然环境或实验室控制激发期间的生理测量确认致病作用。
