转座元件与环状DNA。
Transposable elements and circular DNAs.
作者信息
Mourier Tobias
机构信息
Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology , Thuwal, Saudi Arabia.
出版信息
Mob Genet Elements. 2016 Sep 26;6(6):e1240748. doi: 10.1080/2159256X.2016.1240748. eCollection 2016.
Abstract
Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs). Similarly, circular DNAs can be generated by recombination between LTRs residing at different genomic loci, in which case the circular DNA will contain the intervening sequence. In yeast, this can result in gene copy number variations when circles contain genes and origins of replication. Here, I speculate on the potential and implications of circular DNAs generated through recombination between human transposable elements.
摘要
环状DNA是通过基因组重组事件而环化的染色体外片段。我们最近发现，酵母LTR元件通过其侧翼长末端重复序列（LTR）之间的重组事件产生环状DNA。类似地，环状DNA也可由位于不同基因组位点的LTR之间的重组产生，在这种情况下，环状DNA将包含中间序列。在酵母中，当环状物包含基因和复制起点时，这可能导致基因拷贝数变异。在此，我推测通过人类转座元件之间的重组产生的环状DNA的潜力和影响。
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