EZH2协调顶基极性和神经上皮细胞更新。
EZH2 orchestrates apicobasal polarity and neuroepithelial cell renewal.
作者信息
Akizu Naiara, Martínez-Balbás Marian A
机构信息
Department of Molecular Genomics, Instituto de Biología Molecular de Barcelona (IBMB), Consejo Superior de Investigaciones Científicas (CSIC) , Barcelona, Spain.
出版信息
Neurogenesis (Austin). 2016 Nov 17;3(1):e1250034. doi: 10.1080/23262133.2016.1250034. eCollection 2016.
Abstract
During early stages of neural development, neuroepithelial cells translocate their nuclei along the apicobasal axis in a harmonized manner with the cell cycle. How cell cycle progression and neuroepithelium polarity are coordinated remains unclear. It has been proposed that developmental cues, epigenetic mechanisms and cell cycle regulators must be linked in order to orchestrate these processes. We have recently discovered that a master epigenetic factor, EZH2 is essential to coordinate these events. EZH2 directly represses the cell cycle regulator in the chicken spinal cord. By doing so, EZH2 controls neural progenitor cell renewal and fine-tunes Rho signaling pathway, which is essential to maintain neuroepithelial structure. Our findings point to a new role of EZH2 during development that could have potential implication in other areas as cancer.
摘要
在神经发育的早期阶段，神经上皮细胞的细胞核沿着顶-基轴以与细胞周期协调一致的方式进行移位。细胞周期进程与神经上皮极性是如何协调的仍不清楚。有人提出，发育信号、表观遗传机制和细胞周期调节因子必须相互联系，才能协调这些过程。我们最近发现，一种主要的表观遗传因子EZH2对于协调这些事件至关重要。EZH2直接抑制鸡脊髓中的细胞周期调节因子。通过这样做，EZH2控制神经祖细胞的更新并微调Rho信号通路，这对于维持神经上皮结构至关重要。我们的发现指出了EZH2在发育过程中的一个新作用，这可能在癌症等其他领域具有潜在意义。
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