[代谢综合征患者血清神经特异性蛋白浓度的改变]
[Alterations of serum neurospecific proteins concentrations in patients with metabolic syndrome].
作者信息
Kadyrova I A, Kadyrov A S
机构信息
Karaganda State Medical University, Karaganda, Kazakhstan.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(11):92-97. doi: 10.17116/jnevro201611611192-97.
AIM
Metabolic syndrome (MS) - is a complex of metabolic, hormonal and clinical disorders which are risk factors for cardiovascular disease. The study aimed to determine the markers NSE, GFAP, MMP-9 in patients with MS and to assess their prognostic value in the development of acute stroke.
MATERIAL AND METHODS
A cross-sectional analytical studyincluded 157 patients stratified into 4groups (control group, patients with MS, patients with ischemic stroke and patients with ischemic stroke and MS). Laboratory examinations included measurements of MS parameters(total cholesterol, blood glucose, cholesterol, HDL and LDL, triglycerides) and concentrations of neurospecific markers NSE, GFAP and MMP-9 by ELISA.
RESULTS AND CONCLUSION
A relationship between MS and increased concentration of NSE is found. This indicates the presence of neuronal brain injury in patients with metabolic syndrome. There were no changesin the concentrations of GFAP and MMP-9 in patients with MS.
目的
代谢综合征（MS）是一组代谢、激素及临床紊乱症候群，为心血管疾病的危险因素。本研究旨在测定MS患者的神经元特异性烯醇化酶（NSE）、胶质纤维酸性蛋白（GFAP）、基质金属蛋白酶-9（MMP-9）等标志物，并评估其在急性脑卒中发生发展中的预后价值。
材料与方法
一项横断面分析研究纳入了157例患者，分为4组（对照组、MS患者组、缺血性脑卒中患者组、缺血性脑卒中和MS患者组）。实验室检查包括MS参数（总胆固醇、血糖、胆固醇、高密度脂蛋白和低密度脂蛋白、甘油三酯）的测定，以及通过酶联免疫吸附测定法检测神经特异性标志物NSE、GFAP和MMP-9的浓度。
结果与结论
发现MS与NSE浓度升高之间存在关联。这表明代谢综合征患者存在神经元性脑损伤。MS患者的GFAP和MMP-9浓度无变化。
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