Pan Changduo, Chen Chaoyue, Yu Jin-Tao
School of Chemical & Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, P. R. China.
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou 213164, P. R. China.
Org Biomol Chem. 2017 Feb 1;15(5):1096-1099. doi: 10.1039/c6ob02533a.
Alkyl-substituted isoquinoline-1,3(2H,4H)-diones were prepared by decarbonylative coupling of N-alkyl-N-methacryloylbenzamides and aliphatic aldehydes under metal-free conditions. The reaction undergoes subsequent decarbonylation, radical addition and cyclization processes with aliphatic aldehydes as the cheap and abundant alkyl radical source. This procedure offers a complementary approach to the convenient generation of alkyl-substituted isoquinoline-1,3(2H,4H)-diones.
在无金属条件下，通过N-烷基-N-甲基丙烯酰基苯甲酰胺与脂肪醛的脱羰偶联反应制备了烷基取代的异喹啉-1,3(2H,4H)-二酮。该反应随后经历脱羰、自由基加成和环化过程，以脂肪醛作为廉价且丰富的烷基自由基源。此方法为方便地生成烷基取代的异喹啉-1,3(2H,4H)-二酮提供了一种补充方法。
