未成熟自发性高血压大鼠血液中的一氧化氮、内皮素-1和血清素
Nitrogen Oxide, Endothelin-1, and Serotonin in the Blood of Immature Spontaneously Hypertensive Rats.
作者信息
Chibireva M D, Aflyatumova G N, Matveeva V L, Bilalova D F, Kuz'mina O I, Sadykova D I, Nigmatullina R R
机构信息
Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
Kazan State Medical Academy, Ministry of Health of the Russian Federation, Kazan, Tatarstan Republic, Russia.
出版信息
Bull Exp Biol Med. 2017 Jan;162(3):310-312. doi: 10.1007/s10517-017-3602-8. Epub 2017 Jan 14.
Endothelial function is an early and sensitive marker of subclinical increase of BP in children and adolescents. It is associated with an imbalance of the key vasoactive factors (NO, endothelin-1, and serotonin). Immature spontaneously hypertensive rats (SHR line) are characterized by increased plasma concentrations of NO and endothelin-1 (by 14.7% and 2.9 times, respectively) and increased serotonin content in the plasma and platelets (by 2.7 and 2.3 times, respectively) in comparison with Wistar-Kyoto rats. Platelet count in the blood of SHR rats is by 50% higher than in Wistar-Kyoto rats.
内皮功能是儿童和青少年血压亚临床升高的早期敏感标志物。它与关键血管活性因子（一氧化氮、内皮素-1和血清素）失衡有关。与Wistar-Kyoto大鼠相比，未成熟自发性高血压大鼠（SHR品系）的特征是血浆中一氧化氮和内皮素-1浓度升高（分别升高14.7%和2.9倍），血浆和血小板中血清素含量增加（分别增加2.7倍和2.3倍）。SHR大鼠血液中的血小板计数比Wistar-Kyoto大鼠高50%。
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