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孕激素预防早产的合理应用:推动改善的测量方法

Appropriate Use of Progesterone to Prevent Preterm Birth: Approaches to Measurement for Driving Improvement.

作者信息

Batra Priya, Hirai Ashley, Selk Sabrina, Lee Vanessa, Lu Michael

机构信息

School of Medicine, Center for Healthy Communities, University of California, 900 University Avenue, Riverside, CA, 92521, USA.

Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA.

出版信息

Matern Child Health J. 2017 Mar;21(3):446-451. doi: 10.1007/s10995-016-2234-3.

DOI:10.1007/s10995-016-2234-3
PMID:28092063
Abstract

Introduction Despite strong evidence supporting the benefit of 17-alpha hydroxyprogesterone caproate (17P) in preventing recurrent preterm birth, this treatment still does not reach most eligible patients. This study sought to identify approaches to measuring the appropriate use of 17P, with the goal of helping health systems better monitor and improve the implementation of this intervention. Methods Semi-structured telephone interviews were used to gather data on measures for 17P use being developed and implemented by state team members participating in the Infant Mortality Collaborative Improvement and Innovation Network (IM CoIIN)-a national quality improvement initiative. Strengths and limitations of these measurement approaches were described. Results Six approaches to measuring 17P use to prevent preterm birth were identified: practice-level data, population-based surveys, three measures employing insurance claims with or without linked birth certificate data, and revised birth certificates. Each measure had particular strengths and limitations. Practice-level measures were useful in rapid-cycle improvement, but were not generalizable across sites. In contrast, population-based measures (i.e., surveys, claims) were useful for broad comparisons, but were limited in their timeliness, and in how accurately they identified candidates who were truly eligible for 17P. Additionally, such measures required complex data linkage and analytic capabilities. Discussion A variety of imperfect measures for the appropriate use of 17P are available. No "best" measure was identified-the optimal measurement option must fit the specific needs of a health agency. Better data infrastructure and harnessing information from integrated electronic health records could improve the quality of 17P use measurement for improvement efforts.

摘要

引言 尽管有强有力的证据支持己酸17-α羟孕酮(17P)在预防复发性早产方面的益处,但这种治疗方法仍未惠及大多数符合条件的患者。本研究旨在确定衡量17P合理使用的方法,目标是帮助卫生系统更好地监测和改进这种干预措施的实施情况。方法 采用半结构化电话访谈收集参与婴儿死亡率协作改进与创新网络(IM CoIIN,一项全国性质量改进计划)的州团队成员正在制定和实施的17P使用衡量措施的数据。描述了这些测量方法的优点和局限性。结果 确定了六种用于衡量预防早产的17P使用情况的方法:实践层面的数据、基于人群的调查、三种使用保险理赔并带有或不带有关联出生证明数据的措施,以及修订后的出生证明。每种方法都有其特定的优点和局限性。实践层面的措施在快速循环改进中很有用,但不能在各地点推广。相比之下,基于人群的措施(即调查、理赔)有助于进行广泛比较,但在及时性以及准确识别真正符合17P使用条件的候选人方面存在局限性。此外,这些措施需要复杂的数据关联和分析能力。讨论 对于17P的合理使用,有多种不完善的测量方法。未确定“最佳”方法——最佳测量选项必须符合卫生机构的特定需求。更好的数据基础设施以及利用综合电子健康记录中的信息可以提高用于改进工作的17P使用测量的质量。

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Appropriate Use of Progesterone to Prevent Preterm Birth: Approaches to Measurement for Driving Improvement.孕激素预防早产的合理应用:推动改善的测量方法
Matern Child Health J. 2017 Mar;21(3):446-451. doi: 10.1007/s10995-016-2234-3.
2
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Matern Child Health J. 2018 Nov;22(11):1607-1616. doi: 10.1007/s10995-018-2556-4.
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Impact of 17P usage on NICU admissions in a managed medicaid population--a five-year review.17P 使用对管理式医疗补助人群新生儿重症监护病房入院率的影响——一项为期五年的回顾
Manag Care. 2010 Feb;19(2):46-52.
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Estimated effect of 17 alpha-hydroxyprogesterone caproate on preterm birth in the United States.己酸17α-羟孕酮对美国早产的估计影响。
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Pregnancy outcomes of managed Medicaid members prescribed home administration of 17 α-hydroxyprogesterone caproate.管理医疗补助计划成员在家中使用 17α-羟孕酮己酸酯进行管理的妊娠结局。
Am J Perinatol. 2012 Aug;29(7):489-96. doi: 10.1055/s-0032-1304833. Epub 2012 Mar 7.
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What agent should be used to prevent recurrent preterm birth: 17-P or natural progesterone?用什么药物预防复发性早产:17-P 还是天然孕酮?
Obstet Gynecol Clin North Am. 2011 Jun;38(2):235-46, ix-x. doi: 10.1016/j.ogc.2011.02.014.
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Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth.己酸17-α羟孕酮预防复发性自发性早产疗效的预测因素
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Effectiveness of 17-α-hydroxyprogesterone caproate on preterm birth prevention in women with history-indicated cerclage.17-α-羟孕酮己酸酯预防有指征行宫颈环扎术史孕妇早产的有效性。
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Gestational age at initiation of 17-hydroxyprogesterone caproate (17P) and recurrent preterm delivery.己酸羟孕酮(17P)起始时的孕周与复发性早产
J Matern Fetal Neonatal Med. 2007 Mar;20(3):249-52. doi: 10.1080/14767050601152845.

引用本文的文献

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Comparison of oral Dydrogesterone and 17-α hydroxyprogesterone caprate in the prevention of preterm birth.口服地屈孕酮与 17-α 羟孕酮己酸酯预防早产的比较。
BMC Pregnancy Childbirth. 2022 Mar 1;22(1):167. doi: 10.1186/s12884-022-04509-1.

本文引用的文献

1
Operationalizing 17α-Hydroxyprogesterone Caproate to Prevent Recurrent Preterm Birth: Definitions, Barriers, and Next Steps.将 17α-羟孕酮己酸酯用于预防复发性早产的实施:定义、障碍和下一步。
Obstet Gynecol. 2016 Dec;128(6):1397-1402. doi: 10.1097/AOG.0000000000001738.
2
17-Hydroxyprogesterone caproate (17OHP-C) coverage among eligible women delivering at 2 North Carolina hospitals in 2012 and 2013: A retrospective cohort study.2012 年和 2013 年在北卡罗来纳州的 2 家医院分娩的符合条件的女性中 17-羟孕酮己酸酯(17OHP-C)的覆盖情况:一项回顾性队列研究。
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Births: Final Data for 2014.
出生情况:2014年最终数据。
Natl Vital Stat Rep. 2015 Dec;64(12):1-64.
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Patient characteristics associated with 17-alpha hydroxyprogesterone caproate use among a high-risk cohort.高危队列中与己酸17-α羟孕酮使用相关的患者特征。
Am J Obstet Gynecol. 2016 Apr;214(4):536.e1-536.e5. doi: 10.1016/j.ajog.2015.10.148. Epub 2015 Oct 28.
5
17α-hydroxyprogesterone caproate access in the Louisiana Medicaid population.己酸17α-羟孕酮在路易斯安那州医疗补助计划人群中的可及性。
Clin Ther. 2015 Apr 1;37(4):727-32. doi: 10.1016/j.clinthera.2015.01.007. Epub 2015 Feb 17.
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Why the United States preterm birth rate is declining.为何美国的早产率正在下降。
Am J Obstet Gynecol. 2015 Aug;213(2):175-80. doi: 10.1016/j.ajog.2014.12.011. Epub 2014 Dec 12.
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Assessing the quality of medical and health data from the 2003 birth certificate revision: results from two states.评估2003年出生证明修订版中医疗卫生数据的质量:两个州的结果
Natl Vital Stat Rep. 2013 Jul 22;62(2):1-19.
8
Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth.对被认为有早产风险的女性进行产前孕激素给药以预防早产。
Cochrane Database Syst Rev. 2013 Jul 31;2013(7):CD004947. doi: 10.1002/14651858.CD004947.pub3.
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Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index.预防早产:对人类发展指数极高的 39 个国家进行干预的趋势分析和潜在减少。
Lancet. 2013 Jan 19;381(9862):223-34. doi: 10.1016/S0140-6736(12)61856-X. Epub 2012 Nov 16.
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