可溶性Toll样受体2是入住重症监护病房（ICU）12小时内发生多器官功能衰竭的重症患者脓毒症的生物标志物。
Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission.
作者信息
Holst Benjamin, Szakmany Tamas, Raby Anne-Catherine, Hamlyn Vincent, Durno Kimberley, Hall Judith E, Labéta Mario O
机构信息
Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
ACT Directorate, Cwm Taf University Health Board, Llantrisant, CF72 8XR, UK.
出版信息
Intensive Care Med Exp. 2017 Dec;5(1):2. doi: 10.1186/s40635-016-0116-z. Epub 2017 Jan 13.
Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4-6.1) in sepsis and 0.6 ng/ml (0.4-0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure.
可溶性TLR2水平在感染性和炎症性疾病中升高，但其在脓毒症诱导的多器官功能衰竭中的诊断价值尚未得到评估。本研究纳入了37例诊断为严重脓毒症/脓毒性休克（脓毒症）的患者和27例无感染的器官功能衰竭患者（全身炎症反应综合征，SIRS）。脓毒症患者血浆sTLR2水平的中位数（四分位间距）为2.7 ng/ml（1.4 - 6.1），SIRS患者为0.6 ng/ml（0.4 - 0.9），p < 0.001。当临界值为1.0 ng/ml时，sTLR2对脓毒症具有良好的诊断价值，曲线下面积（AUC）：0.959。我们报告了sTLR2水平在多器官功能衰竭患者入住重症监护病房（ICU）12小时内区分脓毒症和SIRS的能力。
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