de Moraes Silva Melissa A, Ferreira Rimarcs G, de Jesus-Silva Seleno G, Cardoso Rodolfo S, Miranda Fausto
Faculty of Medicine of Itajuba, Federal University of Sao Paulo, Sao Paulo, Brazil.
Phlebology. 2018 Mar;33(2):122-127. doi: 10.1177/0268355516683922. Epub 2017 Jan 16.
Background Sclerotherapy has been gaining increased acceptance and popularity as an effective therapy for the treatment of varicose veins. This attention has fed growing interest into the safety and potential complications of this procedure. There is no evidence of pulmonary complications from foam sclerotherapy in humans; however, animal studies have shown possible damage. The aim of this study is to show the changes in rat pulmonary parenchyma after the injection of 1% polidocanol Tessari foam into the peripheral vein using histological analysis of the inflammatory and fibrosis processes. Methods Twenty-four Wistar rats were divided into the following four groups: 24 h polidocanol, seven-day polidocanol, 28-day polidocanol, and control group. After the foam was injected into the lateral saphenous vein, the lungs of the rats were removed for histological analysis. Results Alveolar edema was observed in only the 24 h group (P < 0.005). Vessel thickening was observed in the seven-and 28-day groups (P < 0.001). Interstitial fibrosis was found in only the 28-day group (P = 0.006). There was no evidence of venous or arterial thrombosis in either group. Conclusion Polidocanol Tessari foam injection into rat peripheral veins causes alveolar edema, vessel thickening, and interstitial fibrosis.
硬化疗法作为治疗静脉曲张的一种有效疗法，已越来越被人们接受和广泛应用。这种关注引发了人们对该手术安全性和潜在并发症的日益浓厚的兴趣。尚无证据表明人类泡沫硬化疗法会引发肺部并发症；然而，动物研究显示可能存在损害。本研究的目的是通过对炎症和纤维化过程进行组织学分析，来展示向大鼠外周静脉注射1%聚多卡醇泰萨里泡沫后大鼠肺实质的变化。方法：将24只Wistar大鼠分为以下四组：聚多卡醇24小时组、聚多卡醇7天组、聚多卡醇28天组和对照组。将泡沫注入大鼠外侧隐静脉后，取出大鼠肺部进行组织学分析。结果：仅在24小时组观察到肺泡水肿（P < 0.005）。在7天组和28天组观察到血管增厚（P < 0.001）。仅在28天组发现间质纤维化（P = 0.006）。两组均未发现静脉或动脉血栓形成的证据。结论：向大鼠外周静脉注射聚多卡醇泰萨里泡沫会导致肺泡水肿、血管增厚和间质纤维化。
