Hu Li-Wen, Yang Mo, Chen Shu, Shah Kuntal, Hailegiorgis Yismaw, Burgens Richai, Vaughn Michael, Huang Jin, Xaverius Pamela, Paul Gunther, Morawska Lidia, Lu Tao, Lin Shao, Zhong Shou-Qiang, Kong Min-Li, Xie Yan-Qi, Hao Yuan-Tao, Zeng Xiao-Wen, Qian Zhengmin, Dong Guang-Hui
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Respiration. 2017;93(3):189-197. doi: 10.1159/000455140. Epub 2017 Jan 17.
Little information exists on whether gender or asthma status modifies the effects of secondhand smoke (SHS) exposure on lung function.
To evaluate whether gender or asthma status modifies the association of SHS exposure with lung function.
A total of 6,740 children (average 11.6 years) were recruited from 24 districts of 7 cities in northeast China in 2012. SHS exposure included exposure to environmental and maternal smoking both in utero and during early childhood (postnatal). Lung function was measured using electronic spirometers. Two-step regressions were used to analyze the association between SHS and lung function.
In utero and postnatal exposure to SHS was independently associated with decreased lung function in both genders; however, this association was greater among males. For example, when exposed to maternal smoking during pregnancy, the adjusted odds ratio (aOR) for decreased forced vital capacity (FVC) was 6.46 (95% confidence interval [CI]: 2.58-16.17) among males, while only 2.16 (95% CI: 0.96-4.88) among females. More positive associations between SHS exposure and decreased lung function were detected among nonasthmatic compared with asthmatic children. Nonasthmatics had significantly larger deficits from in utero exposure to maternal smoking, which concerned decreased lung FVC function (aOR = 2.58, 95% CI: 1.28-5.21) and decreased lung forced expiratory volume in 1 s (FEV1) function (aOR = 2.32, 95% CI: 1.01-5.33). A similar pattern was also observed for the associations between SHS exposure and continuous pulmonary function test measurements.
SHS exposure was associated with decreased lung function. Males and nonasthmatics seem to be more susceptible than their respective counterparts.
关于性别或哮喘状态是否会改变二手烟（SHS）暴露对肺功能的影响，目前所知甚少。
评估性别或哮喘状态是否会改变SHS暴露与肺功能之间的关联。
2012年从中国东北7个城市的24个区招募了总共6740名儿童（平均年龄11.6岁）。SHS暴露包括在子宫内和幼儿期（出生后）暴露于环境烟雾和母亲吸烟。使用电子肺活量计测量肺功能。采用两步回归分析SHS与肺功能之间的关联。
子宫内和出生后暴露于SHS均与两性肺功能下降独立相关；然而，这种关联在男性中更为明显。例如，孕期暴露于母亲吸烟时，男性中用力肺活量（FVC）下降的调整优势比（aOR）为6.46（95%置信区间[CI]：2.58 - 16.17），而女性中仅为2.16（95%CI：0.96 - 4.88）。与哮喘儿童相比，在非哮喘儿童中检测到SHS暴露与肺功能下降之间更多的正相关。非哮喘儿童因子宫内暴露于母亲吸烟而导致的肺功能下降更为显著，这涉及肺FVC功能下降（aOR = 2.58，95%CI：1.28 - 5.21）和肺1秒用力呼气量（FEV1）功能下降（aOR = 2.32，95%CI：1.01 - 5.33）。在SHS暴露与连续肺功能测试测量值之间的关联中也观察到类似模式。
SHS暴露与肺功能下降有关。男性和非哮喘患者似乎比各自的对应人群更易受影响。
