Yano M, Ogawa N, Morita T, Inagaki K, Arai T, Kanazawa T
Nihon Kyobu Geka Gakkai Zasshi. 1989 Aug;37(8):1543-8.
Two patients with human pulmonary dirofilariasis are presented. A 58-year-old woman in Tokyo (Case 1) was pointed out to have a nodular shadow in the right lower field on a routine chest X-ray in 1983. At thoracotomy a 2 cm nodule in the right lower lobe was removed by wedge resection. The nodule was a granuloma containing an immature Dirofilaria species. A 49-year-old man living in Chiba Prefecture (Case 2) was found to have a nodular shadow in the right lower lobe on a chest X-ray in 1987. He was asymptomatic, but laboratory values showed a WBC count of 5,800 with 17% eosinophils. Wedge resection of the lesion was carried out and it was found to be a 2 cm granuloma containing an immature Dirofilaria immitis. The dog heartworm, D. immitis, can occasionally cause pulmonary granulomas in man. More than 50 cases have been reported in Japan, but most of them were diagnosed by postoperative histopathologic examination. Although immunoserological examination or medical treatment were attempted in some cases, they are not established at present. The important thing is that pulmonary dirofilariasis should be included in the differential diagnoses of nodular lesion of the lung.
本文报告了两例人体肺丝虫病患者。一名58岁东京女性（病例1）在1983年的常规胸部X光检查中被发现右下肺野有结节状阴影。在开胸手术中，通过楔形切除术切除了右下叶一个2厘米的结节。该结节是一个含有未成熟丝虫属物种的肉芽肿。一名居住在千叶县的49岁男性（病例2）在1987年的胸部X光检查中发现右下叶有结节状阴影。他没有症状，但实验室检查显示白细胞计数为5800，嗜酸性粒细胞占17%。对该病变进行了楔形切除术，发现是一个2厘米的肉芽肿，含有未成熟的犬恶丝虫。犬恶丝虫偶尔可在人体引起肺部肉芽肿。日本已报告了50多例，但大多数是通过术后组织病理学检查确诊的。尽管在某些病例中尝试了免疫血清学检查或药物治疗，但目前尚未确立。重要的是，肺丝虫病应纳入肺部结节性病变的鉴别诊断中。
