Nichay Nataliya R, Gorbatykh Yuriy N, Kornilov Igor A, Soynov Ilya A, Ivantsov Sergey M, Gorbatykh Artem V, Ponomarev Dmitriy N, Bogachev-Prokophiev Alexander V, Karaskov Alexander M
Department of Congenital Heart Disease, Research Institute of Circulation Pathology, Novosibirsk, Russian Federation.
Department of Anesthesiology, Research Institute of Circulation Pathology, Novosibirsk, Russian Federation.
Interact Cardiovasc Thorac Surg. 2017 Apr 1;24(4):582-589. doi: 10.1093/icvts/ivw429.
This study aimed to evaluate the influence of preserved additional pulmonary blood flow (APBF) on survival after bidirectional cavopulmonary shunt (BCPS) and completion of Fontan circulation.
From March 2003 and April 2015, 156 patients with a single ventricle underwent BCPS. After performing propensity score analysis (1:1) for the entire sample, 50 patients with APBF (APBF group) were matched with 50 patients without APBF (no-APBF group).
Age ( P = 0.90), sex ( P = 0.57), weight ( P = 0.75), single ventricle morphology ( P = 0.87), type of neonatal palliative procedure ( P = 0.52), saturation ( P = 0.35), ejection fraction ( P = 0.90), Nakata index ( P = 0.70) and mean pulmonary artery pressure ( P = 0.72) were not significantly different between the groups. No significant survival difference was demonstrated ( P = 0.54). One and 4-year survival rates were both 89.1% ± 4.6% in the APBF group and 87.2% ± 4.9% and 83.4% ± 5.9%, respectively, in the no-APBF group. There was no significant difference in rates of Fontan completion ( P = 0.24), which was achieved in 22 patients from the APBF group (55.0%) and 26 patients from the no-APBF group (65.0%). However, Fontan completion occurred significantly earlier in the no-APBF group ( P < 0.01). In this group, Fontan procedure was performed before 36 months of inter-stage period in 45.9% ± 8.5% of cases (95% CI 31.0-63.7%) compared to only 13.3 ± 5.6% (95% CI 5.8-29.1%) in the APBF group.
Our study demonstrates that APBF does not affect survival after BCPS or Fontan completion rate. APBF allows postponing the Fontan procedure without a negative effect on clinical status.
本研究旨在评估保留额外肺血流(APBF)对双向腔肺分流术(BCPS)及Fontan循环完成后生存情况的影响。
2003年3月至2015年4月,156例单心室患者接受了BCPS。对整个样本进行倾向评分分析(1:1)后,50例有APBF的患者(APBF组)与50例无APBF的患者(无APBF组)进行匹配。
两组在年龄(P = 0.90)、性别(P = 0.57)、体重(P = 0.75)、单心室形态(P = 0.87)、新生儿姑息手术类型(P = 0.52)、血氧饱和度(P = 0.35)、射血分数(P = 0.90)、中田指数(P = 0.70)和平均肺动脉压(P = 0.72)方面无显著差异。未显示出生存差异有统计学意义(P = 0.54)。APBF组1年和4年生存率均为89.1%±4.6%,无APBF组分别为87.2%±4.9%和83.4%±5.9%。Fontan循环完成率无显著差异(P = 0.24),APBF组22例(55.0%)、无APBF组26例(65.0%)完成了Fontan循环。然而,无APBF组Fontan循环完成时间显著更早(P < 0.01)。在该组中,45.9%±8.5%(95%CI 31.0 - 63.7%)的病例在分期期间36个月之前进行了Fontan手术,而APBF组仅为13.3±5.6%(95%CI 5.8 - 29.1%)。
我们的研究表明,APBF不影响BCPS后的生存情况或Fontan循环完成率。APBF可使Fontan手术推迟,且对临床状况无负面影响。