Safronetz David, Sogoba Nafomon, Diawara Sory Ibrahim, Bane Sidy, Rosenke Kyle, Maiga Ousmane, Boisen Matt, Garry Robert F, Branco Luis M, Lindsay L Robbin, Traoré Sékou F, Feldmann Heinz, Doumbia Seydou
University of Manitoba, Winnipeg, Canada.
Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Canada.
Am J Trop Med Hyg. 2017 Apr;96(4):944-946. doi: 10.4269/ajtmh.16-0821. Epub 2017 Jan 16.
AbstractPreviously, we reported a high seroprevalence rate of Lassa virus antibodies in inhabitants of three villages in southern Mali where infected rodents have been demonstrated. Herein, we report a 1-year follow-up study in which we were able to collect a second blood samples from 88.7% of participants of the same cohort. We identified 23 seroconversions for IgG antibodies reactive against Lassa virus, representing an incidence of 6.3% (95% confidence interval = 3.8-8.8%). Seroconversion was frequently seen in preteenage children (12/23, 51.7%) and two household/familial clusters were identified. These results confirm active transmission of Lassa virus is occurring in southern Mali and appropriate diagnostic testing should be established for this etiological agent of severe viral hemorrhagic fever.
摘要
此前，我们报道了在马里南部三个村庄的居民中拉沙病毒抗体的血清阳性率很高，在这些村庄已证实存在受感染的啮齿动物。在此，我们报告一项为期1年的随访研究，在该研究中我们能够从同一队列88.7%的参与者那里采集到第二份血样。我们鉴定出23例针对拉沙病毒产生反应性IgG抗体的血清转化，发病率为6.3%（95%置信区间=3.8-8.8%）。血清转化在青春期前儿童中很常见（12/23，51.7%），并鉴定出两个家庭/家族聚集性病例。这些结果证实拉沙病毒正在马里南部发生活跃传播，应对这种严重病毒性出血热的病原体建立适当的诊断检测方法。
