多发性硬化症中的热休克蛋白

Heat Shock Proteins in Multiple Sclerosis.

作者信息

Pinar Ortan, Ozden Yildirim Akan, Omur Erkizan, Muhtesem Gedizlioglu

机构信息

Division of Neurology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.

Division of İnternal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.

出版信息

Adv Exp Med Biol. 2017;958:29-42. doi: 10.1007/978-3-319-47861-6_3.

DOI:10.1007/978-3-319-47861-6_3

PMID:28093706

Abstract

Multiple sclerosis (MS) is an immune-mediated and neurodegenerative central nervous system disease, mostly affect myelin sheaths. The MS pathogenesis is still under debate. It is influenced by genetic, environment factors. Heat shock proteins (HSPs) are highly conserved proteins seen in all organisms. Not only heat stress but also under many stress conditions they are overexpressed. Their roles in MS pathogenesis are highly correlated with their location (intracellular or extracellular). In this chapter, we will discuss the role of HSP in MS pathogenesis.

摘要

多发性硬化症（MS）是一种免疫介导的神经退行性中枢神经系统疾病，主要影响髓鞘。MS的发病机制仍存在争议。它受遗传、环境因素影响。热休克蛋白（HSPs）是在所有生物体中都可见的高度保守的蛋白质。不仅在热应激下，而且在许多应激条件下它们都会过度表达。它们在MS发病机制中的作用与其位置（细胞内或细胞外）高度相关。在本章中，我们将讨论热休克蛋白在MS发病机制中的作用。