Igari Hidetoshi, Watanabe Akira, Ichimura Yasunori, Sakurai Takayuki, Taniguchi Toshibumi, Ishiwada Naruhiko
Division of Infection Control, Chiba University Hospital, Japan.
Division of Infection Control, Chiba University Hospital, Japan.
J Infect Chemother. 2017 Apr;23(4):211-213. doi: 10.1016/j.jiac.2016.12.006. Epub 2017 Jan 13.
QuantiFERON-TB gold in-tube has been used for screening latent tuberculosis infection in newly employed health care workers in Japan. There have been a few studies concerning quality control. We retrospectively analysed QuantiFERON-TB gold in-tube results in a hospital in Japan. Interferon-γ values in three blood collection tubes for QuantiFERON-TB gold in-tube were analysed in association with the positivity rate. The data set consisted of health care workers aged 20-29 years during the 7 years between 2010 and 2016. The yearly QuantiFERON-TB gold in-tube positivity rate was 0.9%, 16.4%, 3.0%, 39.3%, 2.8%, 0.9% and 1.5%, and was extremely high in 2011 and 2013. The interferon-γ values in the tuberculosis antigen tube were elevated in these two years, as indicated by higher median and wider interquartile range. The interferon-γ value in the negative control tube was also higher in 2011. The higher interferon-γ values in collection tubes (tuberculosis antigen tube and/or negative control tube) resulted in higher QuantiFERON-TB gold in-tube positivity rate. The distribution of interferon-γ in tuberculosis antigen tube and negative control tube, as evaluated by median and interquartile range, proved to be an effective index for the quality control of QuantiFERON-TB gold in-tube.
全血γ-干扰素释放试验（QuantiFERON-TB gold in-tube）已被用于日本新入职医护人员潜伏性结核感染的筛查。关于质量控制的研究较少。我们回顾性分析了日本一家医院的全血γ-干扰素释放试验结果。分析了全血γ-干扰素释放试验三个采血试管中的干扰素-γ值与阳性率的关系。数据集包括2010年至2016年这7年间年龄在20 - 29岁的医护人员。全血γ-干扰素释放试验的年度阳性率分别为0.9%、16.4%、3.0%、39.3%、2.8%、0.
