Poungvarin N, Ketsa-Ard K
J Med Assoc Thai. 1989 Aug;72(8):421-6.
The investigators conducted a study of low dose aspirin and antithrombotic effectiveness in ischaemic strokes at Siriraj hospital Medical School, Mahidol University from July 1986 to June 1987. Thirty-six patients, 27 males and 9 females were enrolled in the study. The ages of the patients ranged from 33 to 80 years with a mean age of 55 +/- 12 years. Forty-seven per cent of patients had hyperfunction of platelet before treatment which fell to 3 and 0 per cent 24 hours and 7 days after low dose aspirin treatment (75 mg/d). The platelet count was significantly increased to compensate its hypofunction after seven days of treatment. There was no change in euglobulin lysis time, serotonin level in platelet after low dose aspirin treatment. Plasma prostacyclin in ischaemic stroke patients was statistically significantly reduced in comparison to normal subjects (223.8 pg/ml); but there was no further suppression of plasma prostacyclin after low dose aspirin therapy. Thus, we conclude that low dose aspirin (75 mg/d) is effective for antithrombotic effect in ischaemic stroke patients without any suppression of prostacyclin. We do recommend low dose aspirin for recurrent ischaemic stroke prophylaxis as it has fewer side effects, is cheap, easily administered and effective.
1986年7月至1987年6月，研究人员在玛希隆大学诗里拉吉医院医学院开展了一项关于低剂量阿司匹林对缺血性中风抗血栓形成效果的研究。36名患者参与了该研究，其中男性27名，女性9名。患者年龄在33岁至80岁之间，平均年龄为55±12岁。47%的患者在治疗前血小板功能亢进，在接受低剂量阿司匹林治疗（75毫克/天）24小时和7天后，这一比例分别降至3%和0%。治疗7天后，血小板计数显著升高以补偿其功能减退。低剂量阿司匹林治疗后，优球蛋白溶解时间、血小板血清素水平无变化。与正常受试者相比，缺血性中风患者的血浆前列环素在统计学上显著降低（223.8皮克/毫升）；但低剂量阿司匹林治疗后血浆前列环素没有进一步受到抑制。因此，我们得出结论，低剂量阿司匹林（75毫克/天）对缺血性中风患者具有抗血栓形成作用，且不会抑制前列环素。我们确实推荐使用低剂量阿司匹林来预防复发性缺血性中风，因为它副作用较少、价格便宜、易于给药且有效。
