人红细胞摄取甲状腺激素的动力学分析。

Kinetic analysis of the uptake of thyroid hormones by the human erythrocyte.

作者信息

Ball S G, Ramsden D B

机构信息

Department of Medicine, University of Birmingham, Queen Elizabeth Hospital.

出版信息

J Endocrinol. 1989 Oct;123(1):143-8. doi: 10.1677/joe.0.1230143.

DOI:10.1677/joe.0.1230143

PMID:2809486

Abstract

The uptake of 3,5,3'-tri-iodothyronine (T3) by human erythrocytes was shown to occur by two saturable processes. System I (Michaelis constant (Km) = 109 +/- 40 (mean +/- S.D.) nmol/l; maximal velocity (Vmax) = 43 +/- 16 pmol/min per 10(9) cells) was observed over the range 1-50 nmol T3/l whilst system II (Km = 8.8 +/- 8.0 pmol/l; Vmax = 29 +/- 6 fmol/min per 10(9) cells) was observed over the range 1-500 pmol T3/l. At low concentrations (1-500 pmol/l) uptake processes equivalent to system II could be demonstrated for thyroxine and 3,3',5'-tri-iodothyronine also. System II had the properties of a carrier-mediated process.

摘要

人红细胞对3,5,3'-三碘甲状腺原氨酸（T3）的摄取显示通过两个可饱和过程发生。在1-50 nmol T3/L范围内观察到系统I（米氏常数（Km）= 109±40（平均值±标准差）nmol/L；最大速度（Vmax）= 43±16 pmol/分钟/10⁹个细胞），而在1-500 pmol T3/L范围内观察到系统II（Km = 8.8±8.0 pmol/L；Vmax = 29±6 fmol/分钟/10⁹个细胞）。在低浓度（1-500 pmol/L）时，甲状腺素和3,3',5'-三碘甲状腺原氨酸的摄取过程也等同于系统II。系统II具有载体介导过程的特性。